Categories
Epidemiology

Am I Weird If I Still Wear A Mask?

I am in an increasingly small minority of Americans who still wear face masks in public indoor areas. And I feel increasingly self-conscious when I’m the only person wearing a mask. But should I feel that way?

I realized that something had changed when I attended the annual American College of Chest Physicians meeting in Nashville last week. When I preregistered a few months ago, I had to attest online that I agreed to wear a mask at all times while attending convention events. When got to the meeting last week, the instructions had changed to “masks are recommended”. In the meeting rooms, I kept track – overall, only 5% of attendees wore a mask. I’m used to this percentage of mask-wearers at the grocery store but at the meeting were hundreds of the country’s pulmonary and critical care physicians who are more intimately familiar with the danger and transmissibility of COVID-19 than any other segment of the U.S. population. Except while delivering a lecture, I wore an N-95 mask the entire time but could not help to think “Does everyone think I’m weird?“.

During the first year of the pandemic, I spend endless hours caring for critically ill COVID patients in our ICU. I intubated them, performed bronchoscopy on them, and pronounced them dead. Back then, everyone wore a mask – in the hospital, in the grocery store, in the airport. And masks worked. Unlike the majority of Americans, I have made it this far through the pandemic without getting infected. I was even part of a CDC prospective study of high-risk healthcare workers and had to get serial blood antibody tests to determine if I got infected caring for COVID patients. All of the tests were negative. When vaccines became available in December 2020, I got my first vaccination at 7:00 AM the first day they were available. And I’ve gotten all 3 booster vaccinations in the first week that they were offered. Other than being 64-years-old, I have no risk factors for severe COVID. So, you’d think I’d be ready to go back to life as it used to be, without face masks.

The thing is, I just don’t want to get COVID.

Yes, I realize that the chances of me dying if I get infected are pretty slim. But they are not zero and besides, there are a lot of other unpleasant complications of COVID that I’d just as soon avoid.

Just because you’re vaccinated doesn’t mean COVID can’t kill you

The COVID vaccines we now have are great. But like most vaccines, they are not perfect. Data from the CDC shows that in August 2022, people who had the primary vaccine series plus 2 or more boosters were 12-times less likely to die of COVID than unvaccinated people. But still, 1 out of every 200,000 Americans died of COVID that month despite being fully vaccinated and boosted. To put that in perspective, if you are vaccinated, you are still 1,500-times more likely to die of COVID than to win the Powerball lottery.

A relative commented to me recently that “COVID is no worse than the flu“. Unfortunately, it is actually worse… much worse. In a typical season, about 25,000 Americans die from influenza. In 2021, 463,000 Americans died from COVID. In other words, Americans were 18-times more likely to die of COVID than die of influenza. And that was despite strict social distancing, masking, school closures, and work-from-home initiatives in 2021. This graph shows the annual deaths from influenza (blue) compared to deaths from COVID (gold).

COVID causes assorted badness other than death

Last month, I was surf fishing in North Carolina. I got to talking to a fellow fisherman who as a chiropractor in his late 60’s who had a bout of COVID shortly after returning from a trip to Ireland. He was fully vaccinated and boosted but still felt wiped out for several days. Weeks later, he still could not taste or smell anything. Personally, I like to taste and smell. I like to be able to tell the difference between a pice of unseasoned tofu and a medium-rare lamb chop. I enjoy a Mendocino pinot noir a lot more than a bottle of Two-Buck Chuck. I don’t want to give those things up. A study from JAMA this summer found that 56% of people infected with COVID have some loss of taste and smell at the time of initial infection. Of those affected, 12% still had loss of taste and smell 2 years after infection. Although the newer variants of COVID are less likely to affect taste or smell than the original COVID, 44% of those infected with Delta and 17% of those infected with Omicron had loss of taste and smell.

Patients experiencing long COVID symptoms have now become common in primary care practices. A study from this month’s JAMA looked at 1.2 million people infected with COVID and found that 6.2% of people have long COVID symptoms – persistent fatigue in 3.2%, persistent respiratory symptoms in 3.7%, and cognitive dysfunction in 2.2%. The average duration of long COVID symptoms was 9 months in those who required hospitalization for their COVID infection and 4 months for those who did not require hospitalization. However, 15% of people with long COVID had symptoms lasting more than 1 year. It seems to me that wearing a mask is a small price to pay in order to avoid fatigue, shortness of breath, and brain fog.

Although vaccination greatly reduces the chance of severe COVID requiring hospitalization or ICU care, breakthrough infections are common in vaccinated people as well as those with immunity from previous infection. A study in the New England Journal of Medicine found that breakthrough infections in vaccinated people typically caused fever, muscle aches, loss of taste/smell, and cough. These symptoms lasted more than 14 days in 31% of people and 23% of people had to take off more than 10 days of work due to symptoms. In short, it is no fun to have a breakthrough COVID infection even though you will probably survive it.

The CDC’s COVID dashboard indicates that the number of COVID cases in the U.S. is falling – only 260,000 new infections were reported last week – down from 5.6 million new cases nine months ago during the third week of January 2022. However, the current prevalence numbers underestimate the true number of new covid infections because many people either choose to not be tested or test themselves using over-the-counter COVID home tests. Either way, these cases do not get reported to local public health departments and are thus not included in the CDC’s data. The bottom line is that tens of thousands of Americans are still getting COVID infections every day.

The social pressures to wear masks

The psychology of masking and unmasking is complex and was nicely described in an essay by blogger JTO, PhD. The various psychological concepts that contribute to people disliking masked people when they themselves are not wearing masks include cognitive dissonance, confirmation bias, psychological reactance, and hostile attribution bias. The net effect of these is strong peer pressure to conform when those around you are not wearing masks.

Social psychologist Dr. Wendy Treynor has proposed a theory of peer pressure called “identity shift effect”. According to this hypothesis, a person’s internal harmony is disrupted a person fails to conform to a group standard resulting in a threat of social rejection. In order to eliminate this threat, the person changes their behavior to conform to the group but in doing so, causes internal conflict because that person has now violated their own code of conduct. To eliminate this internal conflict, the person undergoes an “identity shift” and adopts the group’s standards as their own, thereby eliminating internal conflict and restoring internal harmony. The net result is that the person adopts a new attitude.

For example, if you go to a restaurant wearing jeans because you don’t like getting dressed up and everyone else in restaurant is wearing an evening dress or a suit, you will experience a great deal of psychologic disharmony. The next time you go to the restaurant, you wear a dress or a suit in order to avoid the disharmonious feelings, even though in the past, you didn’t like wearing formal attire.

As human beings, we strive to be accepted by groups of other people. Even non-conformists are often trying to conform to the behavior of other non-conformists to prove that they are just as much of a non-conformist as the other non-conformists.

When you wear a face mask in a store full of unmasked customers or in a church full of unmasked parishioners, you start thinking: “Do they think I’m weak?” or “Do they think I’m a coward?” or “Do they think I’m the one who is contagious?” Fortunately, wearing a mask is not as much of a violation of social norms as wearing a MAGA hat to an ACLU convention or wearing a Cincinnati Bengals jersey in a Pittsburgh sports bar. But nevertheless, there is increasing peer pressure to take one’s mask off.

The advantage of being old

One of the wonderful things that happens when you retire is that you now have the luxury of doing what you want to do rather than what everyone else is doing. Even so, I find myself sometimes apologizing for wearing a mask when no one else is. I’ll sometimes offer up excuses such as “Sorry, I worry too much because I’m a senior citizen” or “I’m going to visit my pregnant daughter and don’t want to risk exposing her“. Most people who I pass in a store or airport just think I’m weird. But I can live with that because I plan to enjoy a healthy life for many more years. Life is just too short to waste days or weeks of it being sick. So, I’m OK with being weird.

October 28, 2022

Categories
Epidemiology

Is Natural Immunity Better Than Vaccination Immunity Against COVID?

There are two ways to become immune to COVID-19: either from previous infection (natural immunity) or from vaccination. But is one better than the other? Many people believe that anything “natural” is better than “artificial” and consequently some pundits, influencers, and bloggers advocate for for natural immunity over vaccination immunity. The COVID Nationwide Antibody Surveillance Survey reported that by February 2022, 58% of Americans had been infected with COVID-19 and thus have some degree of natural immunity. The most recent CDC vaccination data shows that 80% of Americans have received at least 1 dose of a COVID vaccine and 68% have received 2 doses with resultant vaccination immunity. Therefore, most Americans have some degree of immunity one way or the other. Employers and governments are now grappling with whether to mandate vaccination or proof of previous infection as workers return to in-person workplaces.

Summary Points:

  • Viral infection and vaccination stimulate the immune system differently.
  • Either type of immunity is better than no immunity.
  • People with natural immunity from past infection can improve their immunity by getting vaccinated

 

Immunology 101

At the risk of oversimplification, there are two main components of our immune systems – cellular and humoral. Cellular immunity involves T-lymphocyte cells that help fight infection. Humoral immunity involves immunoglobulins (antibodies) that help fight and prevent infection; immunoglobulins are produced by B-lymphocytes. There are five types of immunoglobulins but the three types that are most important for preventing viral infection are IgG, IgM, and IgA. All three of these types of antibodies can be found in the bloodstream but mostly IgA is found on the surface of respiratory cells, such as in the mucus that lines the airways and nasal passages.

When a person gets infected with a virus, the virus uses special molecules on its surface that can bind to cells and then slip inside those cells. These surface molecules are like keys that open the cells allowing the virus to get in. Once inside of a cell, the virus takes over the cell and causes the cell to start to manufacture thousands of copies of the virus (its like what happened to people in the movie Alien). The cell then dies and releases all of the newly manufactured viruses that can then infect more cells.

https://www.gao.gov/products/gao-20-472sp
CNX OpenStax, CC BY 4.0 <https://creativecommons.org/licenses/by/4.0>, via Wikimedia Commons

Once infected with a virus, the body’s immunologic response is to create antibodies to pieces of the virus. Antibodies first start to be produced by B-lymphocytes 5-7 days after an infection with the first antibodies being IgM. Within days to weeks, some of the B-lymphocytes switch to making IgG plus IgM antibodies and the levels of IgM antibodies quickly fall. Over time, the quantity of IgG antibodies in the bloodstream also gradually falls but when the body is re-infected with the same virus, memory B-lymphocytes that had previously been “taught” to make specific antibodies against that virus can ramp up production very quickly resulting in high IgG levels in 1-2 days.

Antibodies fight viral infections in three ways. First, they bind to molecules on the surface of viruses that attach to cells. This is like covering up the “key” so that the virus cannot attach to and get inside of cells. Second, when antibody-coated viruses do get inside of a cell, that cell uses the antibodies as a signal to the rest of the immune system that it is infected, causing other immune cells to attack and kill the cell before it can produce new viruses. Third, when viruses are coated with antibodies, immune cells called macrophages recognize them and “eat” the viruses. The macrophages then digest the viruses and destroy them.

Respiratory viruses, like COVID-19, are first inhaled into the nose and respiratory tract where they get stuck in the mucus that lines those passages. The viruses then infect airway cells and eventually get into the bloodstream where they are carried throughout the body and can infect cells in the heart, liver, brain, muscles, etc. IgA in the mucus of the airways (mucosal immunity) is the first line of defense when a person inhales COVID-19 viruses. IgG in the bloodstream (systemic immunity) is the next line of defense once the COVID-19 virus gets past the airway cells and invades the body.

Olgamatveeva, CC BY-SA 4.0 <https://creativecommons.org/licenses/by-sa/4.0>, via Wikimedia Commons

Antibodies do not always prevent viruses from getting into the body, they just prevent viruses from getting out of control. Since the memory B-cells take 1-2 days to ramp up antibody production, the virus will have a 1-2 day head start to begin to infect cells and reproduce. However, in those first 1-2 days of infection, there are not too many viruses in the body and so a person usually has no symptoms early on (this is the incubation period). Thus neither natural nor vaccination immunity necessarily prevents viruses from getting into the body, they primarily prevent the infection from becoming severe and hopefully prevent you from dying of the infection. In this sense, a viral infection is similar to a mouse infestation in your house – mouse traps in your kitchen can stop the mice from reproducing and eating all of the food in your house but they won’t prevent the mice from getting into the house in the first place.

Because antibodies do not usually prevent viruses from getting into the body and starting to initially reproduce, people with either natural or vaccination immunity can still be contagious to others in those first few days after a virus gets into their body, even though they have no symptoms. The good news is that the number of viruses in the air that they exhale is low and the lower the number of viruses in the air, the less likely it is that someone else breathing that air will become infected.

When a person is infected with COVID, B-lymphocytes in the airways are stimulated to produce anti-COVID IgA antibodies that is released into the airway mucus. Once the COVID virus gets into the bloodstream, blood B-lymphocytes are stimulated to make anti-COVID IgA, IgM and IgG antibodies that are released into the blood. These antibodies recognize different molecules on the surface of the virus and because there are lots of different surface molecules, there are lots of different types of IgA, IgM, and IgG antibodies produced. In other words, COVID-19 infection results in many different types of IgG antibodies. This is different than vaccination immunity.

When a person is vaccinated against COVID, the vaccine is injected into the muscles and then the vaccine gets into the bloodstream. As a result, most of the B-lymphocytes that get stimulated are bloodstream lymphocytes and not airway lymphocytes. These are the lymphocytes are mainly responsible for producing IgM and IgG. B-lymphocytes in the blood also produce some IgA that stays in the blood but since the airway B-lymphocytes are not stimulated, very little airway mucus IgA gets made. Vaccination immunity to COVID also differs from natural immunity because of the types of IgG that are produced. The original Anti-COVID vaccines only produce antibodies against one part of the “spike protein” which is a the molecule on the surface of the virus that the virus uses to attach to cells. If the virus mutates and the spike protein molecule changes shape (as happened with the Omicron variant), then the antibodies produced from vaccination immunity may not recognize this new shape and may be less effective. The new booster COVID vaccines are bivalent and produce antibodies against a part of the spike protein on the original COVID virus and also against a part of the spike protein on the newer Omicron variant.

Natural COVID immunity

Natural immunity to COVID refers to immunity caused by previous infection by COVID. Some people (for example, quarterback Aaron Rodgers) falsely claim “natural immunity” from homeopathic treatments but this is NOT natural immunity. The only ways to develop immunity to COVID is to either have previously been infected by COVID or be vaccinated against it. Because of the different ways that natural immunity and vaccination immunity affect the body’s immune system, both forms of immunity have advantages and disadvantages.

Advantages of natural immunity:

  1. Bloodstream IgG production. Human B-lymphocytes have been making IgG in response to infection by various viruses for hundreds of thousands of years and our B-lymphocytes have gotten very good at it.
  2. More types of IgG antibodies. Because infection with COVID results in many different types of antibodies against many different parts of the surface molecules of the virus, there is a better chance that some of those antibodies will still work against the virus if a new variant arises with a different shape to just one of the surface molecules. A January 2022 study in the MMWR found that prior to the emergence of the Delta variant, people who were vaccinated were less likely to become infected than people who had previously had a COVID infection but after Delta emerged, those with a previous COVID infection were better protected against future infection than those who were vaccinated. Similarly, a study published two months ago found that previously vaccinated people were 13-times more likely to have a breakthrough infection with the Delta variant than previously infected but unvaccinated people.
  3. More mucosal IgA antibodies. Because the COVID virus first stimulates airway B-lymphocytes, those lymphocytes can “learn” to make anti-COVID IgA that gets into the mucus of the nose and airways. Since mucus IgA is the first line of defense, if a person gets re-infected with COVID at a later time, that mucosal IgA can kill off the viruses before they can get into the bloodstream.

Disadvantages of natural immunity:

  1. Lower levels of IgG antibodies. Our immune systems are like muscles, they work best when they continue to train. The more you repstimulate the humoral immune system, the stronger it gets. A COVID-19 infection results in a one-time stimulation to the immune system and this can result in lower antibody levels than in a person whose immune system is stimulated by 2 doses of a vaccine followed by booster doses. Some people produce little or no antibodies after infection. A study from September 2021 found that only 64% of people with severe COVID infections causing ARDS had detectable IgG or IgA antibodies after they recovered from infection.
  2. You only get natural immunity if you survive the infection. More than 1 million Americans have died of COVID infection. These people’s immune systems never got a chance to make antibodies for long-term protection. Even for those who survived the initial infection, the results of the infection are usually feeling really, really bad for a few days and often having long-term loss of taste and smell. Furthermore, long-COVID symptoms occur in one out of every five people infected. Thus, the cost of natural infection is very high.

Vaccination immunity

Because of the different way that COVID infection and COVID vaccination affect the immune system, there are different advantages and disadvantages with vaccination immunity.

Advantages of vaccination immunity:

  1. Bloodstream IgG production. All vaccines work by teaching the body’s immune system to make antibodies and the COVID vaccines are no different.
  2. High levels of IgG antibodies. The initial vaccination consists of 2 dose of the vaccine, given 3 weeks apart. This results in the humoral immune system being stimulated twice, as opposed to actual infection with COVID which only stimulates the immune system once. Getting booster vaccinations results in a third, fourth, and fifth time that the immune system gets stimulated. This “trains” the immune system to get very good at producing anti-COVID antibodies. A study from July 2022 found that antibody levels after mRNA vaccine administration were higher and lasted longer than antibody levels after COVID infection.
  3. Better protection if variants do not occur. A study from August 2021 found that prior to the emergence of the Delta variant, people who had been infected with COVID but not vaccinated (natural immunity) were 2.3-times more likely to become reinfected than people who were vaccinated but never previously infected (vaccination immunity).
  4. You don’t have to get sick to become immune. Although it is true that COVID vaccines can cause side effects, scientific studies as well as my own personal experience show that the side effects of vaccination are way, way, way less than the symptoms of a COVID infection. I have now had 5 different COVID vaccinations and I would take the side effects of all of them combined over even a mild case of COVID infection any day.
  5. The vaccines won’t kill you. The vaccines are safe. A study of 11 million people vaccinated with the Pfizer or Moderna vaccines found that there was no increased risk of mortality by getting vaccinated. On the other hand, about one out of every 100 people who get a COVID infection die from the infection. Even those people who survive the initial COVID infection are 233% more likely to die in the year after infection than people who do not get infected based on a study published last December. To put the mortality numbers in perspective, you are 3 million times more likely to die from a COVID infection than to have a winning Powerball ticket.
  6. Vaccination after a COVID infection improves immunity. A study from July 2022 found that the effectiveness of infection was 46%, the effectiveness of three doses of a vaccine was 52% but the effectiveness of infection plus three doses of a vaccine was 77%. This is sometimes called “hybrid immunity”.

Disadvantages of vaccination immunity:

  1. Single type of IgG antibody. Since the original vaccines resulted in IgG against a specific part of the COVID spike protein, if there is a change in that protein, then the antibodies may not work as well. This was a particular problem with the Omicron variant that caused infection in many people who had been vaccinated earlier. However, even though the vaccines do not work as well if the virus mutates, they do still work and as a result, vaccinated people who get a COVID infection will have milder cases of the infection than unvaccinated people. The newer booster vaccines are bivalent and result in production of two types of antibodies which improves the effectiveness against variants.
  2. Lower mucosal IgA levels. Because the airway B-lymphocytes are not strongly stimulated by vaccination, there is lower anti-COVID IgA in the mucus of vaccinated persons compared to those who have previously had a COVID infection. Thus vaccinated persons may not have as strong of a first-line defense against infection. A study from 2021 found that vaccination causes high levels of IgA and IgG in the bloodstream but little to no IgA in the saliva. A study from July 2022 found that infection with the Omicron variant of COVID resulted in 10-times more IgA in respiratory secretions (bronchoalveolar lavage fluid) than vaccination. A second study from October 2022 also found that people previously infected with COVID had higher mucosal IgA levels than vaccinated but not previously infected people.

What does all of this mean?

So, is natural immunity better than vaccination immunity? Well, it depends… We can draw several conclusions from all of the above findings:

  • If variants do not emerge, vaccination immunity is better than natural immunity.
  • The more boosters a person gets, the better their protection.
  • If variants emerge, natural immunity may be stronger than vaccination immunity until new vaccines are developed against those variants.
  • Natural immunity plus vaccination immunity (hybrid immunity) gives the strongest protection.
  • Although early studies are promising, it is too early to tell if the new boosters that cover Omicron will be better than natural immunity.

For employers trying to decide about whether to mandate vaccination for employees, it is hard to defend a position that vaccination is superior to natural immunity in every case. For example, a person who received 2 shots of the original mRNA vaccines in 2021 may have less immunity than a person who survived an Omicron infection in 2022. Instead of vaccination mandates, a better approach would be immunity mandates by having employees either provide documentation of vaccination or documentation of past infection. However, Americans as a society dislike mandates of any kind and so rather than mandates, it may be better to link immunity documentation to health insurance premium prices, life insurance premium prices, or other employment fringe benefits.

My recommendation is that everyone should get vaccinated and then get as many boosters as you can, including the newest booster that covers Omicron. In theory, immunity from these new boosters should be better than having natural immunity alone. If you have previously had a COVID infection (and are still alive), then get vaccinated and also get the new booster… you can relax with the knowledge that you will then probably have the best immunity against COVID on the planet. We have come to a point in the pandemic where having no immunity (neither natural nor vaccination immunity) is socially irresponsible and only prolongs the pandemic for the rest of us.

October 20, 2022

Categories
Epidemiology Inpatient Practice Outpatient Practice

2022-23 Influenza Season Predictions

You would think that August would bring a lull in the work of U.S. influenza epidemiologists. But August is when we get some of the most important information that predicts what our winter flu season will look like. And the projections are a little scary this year.

The best predictors of North American influenza in our winter is Australian influenza during our summer. Normally, influenza season in Australia starts in April and runs through October, corresponding with winter in the Southern Hemisphere. What happens with influenza in Australia usually fairly closely matches what happens later in the year in the United States. Thus, by examining the epidemiological data from the Australian Department of Health’s Influenza Surveillance, we can predict when influenza cases will start to be seen, what age groups will be affected, what serotypes will be predominant, and what severity will occur here in the United States and Canada.

Recent U.S. influenza seasons

Over the past 3 influenza seasons, we have seen an inverse relationship between COVID cases and influenza. One of the primary reasons for fewer influenza cases when COVID cases increase is social distancing and mask-wearing to prevent COVID. It turns out that these measures help prevent COVID but they are even more effective to help prevent influenza. We can see that effect in the 2019-20, 2020-21, and 2021-22 influenza seasons.

The graph above shows seven previous influenza seasons in the United States. The 2019-20 influenza season (green line) started off quite severe with sustained high numbers of cases from December through March. The onset of the COVID pandemic in the United States in March 2020 marked the closure of schools, work from home initiatives, and public masking. This coincided with a precipitous fall in influenza-like infections at the end of March.

The 2020-21 influenza season (pink line) was the mildest in recent history with only a small peak in cases of influenza-like infections in November and December. At this time, social distancing and masking were more ubiquitous and the COVID vaccines were not yet widely available. It was not until the summer of 2021 that influenza-like infections began to rise – this was a time when COVID vaccines were widely available and it was generally believed that the end of the COVID pandemic was in sight. Consequently, mask mandates were discontinued, children returned to schools, and workers returned to their workplaces. This created conditions that allowed influenza to have a summer rebound.

The 2021-22 season is in red with red triangles. It peaked in December, much earlier than usual. This coincides with the rise in case numbers of the Omicron variant of COVID that caused people to resume masking and social distancing in December. Once these measures to prevent the spread of COVID went back into effect in December 2021, the frequency of influenza-like infections fell.

The exceptional influenza season was the H1N1 outbreak in 2009-10 when cases began to increase in August and peaked in September and October. This represented an unusually early influenza season that caught physicians off-guard. Making matters worse, this particular H1N1 strain had not circulated for decades and was not predicted to appear that season with the result that it was not covered by that season’s flu shots. These factors together resulted in an unusually large number of cases and large numbers of deaths, particularly among younger people who had no natural immunity to H1N1.

What we are learning from Australia

When will influenza season start?

In the last several years, the influenza season in the U.S. has mirrored the influenza season in Australia that occurs earlier in the year. So, what is Australia telling us this year? First, we are likely to see influenza cases start to increase earlier than normal this season. The graph below shows the last several seasons of positive influenza testing in Australia.

The current influenza season is in red. It began much earlier than in past years and also peaked much earlier. Cases began to rise in late April which corresponds to late October in the Northern Hemisphere. Cases peaked in late May in Australia which corresponds to late November in the U.S. By late July, the Australian influenza season was pretty much over – this would correspond to late January in the United States and Canada. So based on these data, we should expect to see influenza cases start to increase in October 2022 with peak numbers in November and December 2022.

How severe will influenza be this year?

Hospitalization data from Australia predicts that this will be an average year with respect to influenza severity. The graph below shows the number of influenza hospitalizations in Australia over the past several seasons. The current season is in red with hospitalizations mimicking the case number graph above. Hospitalizations began to increase in April and were back to baseline by late July. 

Based on this data, in the United States, we should expect influenza-related emergency department visits and hospitalizations to peak in November and December 2022.

What ages will be most affected?

A unique finding during the current Australian influenza season has been the propensity to affect children. The graph below shows the number of laboratory-confirmed influenza cases by age.

The largest case rates have been in people under age 20. This would predict that U.S. pediatricians will be seeing more influenza than U.S. internists this season.

Will the influenza vaccine cover it?

The vast majority of cases of influenza in Australia were influenza A with unusually few cases of influenza B as shown in the graph below.

The seasonal influenza vaccines in Australia this year included the following serotypes:

Egg-based quadrivalent influenza vaccines:

  1. A/Victoria/2570/2019 (H1N1)pdm09-like virus;
  2. A/Darwin/9/2021 (H3N2)-like virus;
  3. B/Austria/1359417/2021-like (B/Victoria lineage) virus; and
  4. B/Phuket/3073/2013-like (B/Yamagata lineage) virus.

Cell-based quadrivalent influenza vaccines:

  1. A/Wisconsin/588/2019 (H1N1)pdm09-like virus;
  2. A/Darwin/6/2021 (H3N2)-like virus;
  3. B/Austria/1359417/2021 (B/Victoria lineage)-like virus; and
  4. B/Phuket/3073/2013 (B/Yamagata lineage)-like virus.

Although it is still too early to be confident of Australian vaccine effectiveness, we can look at whether the strains seen during the flu season corresponded to the strains covered by the influenza vaccines. In all, 97.4% of influenza A (H1N1) isolates were antigenically similar to the vaccine components. 93.2% of influenza A (H3N2) isolates were antigenically similar to the corresponding vaccine components. And all of the influenza B isolates were similar to the corresponding vaccine components. The U.S. quadrivalent influenza vaccine for the 2022-23 season has identical components to the egg-based quadrivalent influenza vaccine used in Australia. Therefore, it is likely that this season’s flu shots will cover the strains of influenza that we are likely to see in North America.

What we should do in the U.S.

Based on the Australian experience, there are several steps that we should take to prepare ourselves for the 2022-23 influenza season:

  1. Start vaccinating early. It takes about 2 weeks for immunity to develop after a flu shot. Therefore, we should insure that most Americans get vaccinated in September this year if case numbers begin to rise in October as anticipated. If cases peak in late November, as expected, then people who wait until December or January to get vaccinated will have waited too long.
  2. Target kids for vaccination. With children being disproportionately affected by influenza in Australia, it is likely that we will see the same trend in the U.S., particularly as schools return to in-person classes.
  3. Prepare for a surge of hospitalizations in November and December. Normally, this is a low-census period for medical admissions in American hospitals. It is also a time when many people get elective surgeries over the winter holidays and before the end of the calendar year to take advantage of annual insurance deductibles. If the early influenza peak occurs as expected, we may need to institute routine pre-op influenza testing for elective surgeries much as was done with COVID testing during the worst of the COVID pandemic.
  4. Anticipate the effect of Thanksgiving travel. Thanksgiving and Christmas holidays are times when many Americans travel to be with family. The Australian influenza season predicts that U.S. influenza cases may be peaking around Thanksgiving. This could result in holiday travel accelerating influenza spread this year.

No one can predict the influenza season with 100% accuracy. But if historical trends follow, then the U.S. will likely experience a similar season as Australia. Given that most Americans are starting to relax as the COVID-19 case numbers fall, we could be especially vulnerable to influenza this year, particularly if it comes early and preferentially affects children as expected.

August 10, 2022

Categories
Epidemiology

Public Health Hall Of Shame Nominees

The NFL has a hall of fame in Canton. Cooperstown has the baseball hall of fame. There is even a polka hall of fame in Euclid, Ohio. It is time to create a memorial to prominent figures in public health but instead of a hall of fame, I propose we create a hall of shame to recognize people whose actions have promoted disease, injuries, and death. Here are 10 people worthy of induction into the Public Health Hall of Shame, listed in chronological order.

1. Christopher Columbus

Unlike many of of the Hall of Shame nominees, Christopher Columbus did not knowingly promote the spread of disease but his inadvertent actions make him worthy of inclusion. He was the first worldwide disease importer/exporter. On October 12, 1492, Columbus arrived in the Bahamas bringing to the newly discovered lands European diseases. When he returned to Spain on March 15, 1493, he brought gifts from the New World. One of those gifts carried by crew members was syphilis that then spread to Spanish soldiers. Two years later, in 1495, Pope Innocent VIII invited King Charles of France to wage war against the King of Naples in Italy. Spanish mercenaries employed by the French army brought syphilis with them to Naples and within a few years, syphilis had spread throughout Europe. Because of the association with the French army, syphilis became known as the “French disease” but it was really the Spanish sailors who brought it back with them from the Americas. Recently, historians have proposed that syphilis occurred sporadically in Europe before Columbus sailed but given the correlation with the Naples war, it seems likely that his crew carried the infection on their return to Spain thus fostering its European spread in the 16th century. For his contribution to the spread of syphilis to Europe (even though inadvertently), Christopher Columbus is nominated to the Hall of Shame.

2. Hernán Cortés

Another Spaniard who warrants inclusion in our Hall of Shame was the conquistador, Hernán Cortés. He was from a lesser nobility family in Spain but chose to come to the New World to seek gold and silver rather than live the life of a nobleman in Europe. In February 1519, he sailed from Cuba to Mexico in order to conquer the Aztecs and loot their empire. His force of 1,000 men was no match for the 200,000 residents in the Aztec capital of Tenochtitlan in Central Mexico. But Cortés had a secret weapon… smallpox. One of Cortés’ soldiers had become infected with smallpox before leaving Cuba. The Aztecs and other Native Americans had no immunity to smallpox because it had not existed in the Americas until it was brought by the early European explorers. 70 days after Cortés first arrived in Mexico, 40% of the population of Tenochtitlan was dead from smallpox. Within a few years, between 5-7 million Aztecs and other indigenous Mexicans died from smallpox. Cortés proved that infectious diseases are more powerful in battle than swords and cannon. In all, it is suspected that infectious diseases brought by European explorers resulted in the death of up to 95% of the native population of the Americas. For his actions resulting in the deaths of millions of Native Mexicans due to smallpox, Hernán Cortés is nominated to the Hall of Shame.

Honorable mention: Colonel Henry Bouquet. In June 1763, Bouquet was the commanding officer at Fort Pitt during Potomac’s War. When the fort was under siege by members of the Delaware Tribe, Bouquet needed help to defeat the Native Americans. So, he ordered his men to distribute smallpox-infested blankets to the besieging warriors in an attempt to infect them and reduce their forces. More than 100 Native Americans died from the resultant smallpox outbreak. Bouquet can be considered the father of germ warfare.

3. Anthony Comstock

In 1873, U.S. postal inspector Anthony Comstock formed the New York Society for the Suppression of Vice. Later that year, he lobbied the U.S. Congress to pass what became known as the Comstock Act that prohibited the postal service from delivering obscene material. As a result, more than 15 tons of books that Comstock determined were obscene were destroyed. These included anatomy books used by medical schools because those books included drawings of reproductive organs. Another provision of the Comstock Act was to prohibit the production of or publication of information about methods of contraception or prevention of venereal disease. Comstock was convinced that by making condoms illegal that Americans would stop having sex outside of marriage. He was oblivious to the fact that the drive to have sex is the most powerful drive in all species of living organisms on planet Earth. He zealously prosecuted and imprisoned anyone who defied his definition of morality, including Julius Schmidt, the inventor of the rubber condom. After release from prison, Schmidt resumed condom manufacturing in a clandestine production facility in New York City. During World War I, being unable to legally sell his condoms to the U.S. Army because of the Comstock Act, Schmidt turned to other allied governments that enthusiastically purchased and distributed condoms to their servicemen. As a result, unlike other Allied armies, at any given time, approximately 15% of the U.S. military force in Europe was actively infected with a venereal disease. Eventually, the U.S. government relented and the production and distribution of condoms became legal but not before Comstock’s efforts had resulted in tens of thousands of cases of syphilis and gonorrhea that could otherwise have been prevented. For his efforts to promote the spread of sexually transmitted disease, Anthony Comstock is deserving of induction into the Hall of Shame.

4. Mary Mallon

From 1900 to 1907, Mary Mallon worked for eight wealthy New York families as a cook. At each household where she worked, household members developed typhoid fever. When a public health investigator determined that Ms. Mallon was the common link in the series of typhoid outbreaks, he went to interview her. But when he asked her to provide samples to test, she attacked him with a fork. She was sentenced by the Health Department to quarantine at North Brother Island from 1907 – 1910. She was released from quarantine under the condition that she never resume work as a cook again. However, she went back to cooking for families, restaurants, and hospitals under a false name. Everywhere she went, she left a trail of typhoid cases. In 1915, when 25 inpatients developed typhoid at a hospital where she worked as a cook, she was again sentenced to quarantine at North Brother island where she lived for 23 years. For her efforts to spread typhoid fever as an asymptomatic carrier, she earned the name “Typhoid Mary” and warrants induction into the Hall of Shame.

5. Emma Marie Harrington

Also known as E.C. Harrington, she was an attorney and the first woman registered to vote in San Francisco. She was a champion of progressive issues in California in the early 1900’s. However, she became famous for her actions that today would make her the darling of political conservatives. In March 1918, an army cook at Camp Funston in Kansas became sick with a respiratory infection. Within days, 522 soldiers became ill. Because the U.S. had entered World War I, troops from Camp Funston were sent to Europe to fight. By April, the H1N1 strain of influenza had spread throughout the world. Within 2 years, one-third of the world’s population had become infected. The number of deaths were estimated to be as high as 100 million making it the second most deadly pandemic after the 14th century bubonic plague. Because there were no vaccines or anti-viral medications at that time, the only defense against influenza was to avoid getting it in the first place. The two public health measures that were found to reduce the spread of the infection were face masks and banning mass gatherings. But some Americans considered face mask mandates to be an affront to personal liberty. Many of them organized to oppose face masks which they called “muzzles”. One of these organizations was the San Francisco Anti-Mask League and E. C. Harrington was its president. During the fall of 1918 and early winter of 1919, more than 3,000 San Francisco residents had died from influenza and the death rate per 100,000 was one of the highest in the world. Despite magnitude of deaths, the Anti-Mask League put enormous political pressure on the city government to lift its mask ban. On January 27, 1919, Mrs. Harrington submitted a petition to the city’s Board of Supervisors to repeal the mask ordinance and 5 days later, on February 1, 1919, San Francisco lifted its mask requirement. For helping to promote influenza deaths in 1919 and for later inspiring thousands of anti-maskers during the COVID-19 pandemic, E. C. Harrington deserves nomination into the Hall of Shame.

6. John W. Hill

America’s economic fortunes were built on tobacco. When anticipated riches from early settlements such as Jamestown failed to materialize, the settlers turned to growing tobacco for export to Europe. Demand for tobacco was enormous and soon farms and plantations across the colonies were making their fortunes by growing tobacco. The invention of a machine for large scale manufacturing of cigarettes in 1880 revolutionized the U.S. tobacco industry. After the turn of the century, per capita cigarette consumption increased exponentially. But by 1950, there were increasing reports that tobacco smoke could be harmful to people’s health. The CEOs of the largest cigarette makers – American Tobacco Co., R. J. Reynolds, Philip Morris, Benson & Hedges, U.S. Tobacco Co. and Brown & Williamson, were worried that sales would suffer so they turned to John W. Hill, the founder of Hill & Knowlton, one of the top public relations firms in the country. In 1953, Hill devised a PR campaign to discredit the mounting scientific data and named it “Operation White Coats”. The plan was to employ physicians and scientists (who wore white coats) to downplay the health hazards of cigarette smoke. Operation White Coats was the genesis of the Tobacco Research Council that provided easy-to-obtain grants to prominent medical researchers for studies that showed health benefits of nicotine and other tobacco components. Hill’s cigarette marketing strategy was successful and by 1965, 45% of U.S. adults were daily smokers. In reality many people have contributed to the the misinformation campaigns of American tobacco companies but John W. Hill stands out as of the most effective in denying that smoking cigarettes causes lung cancer, COPD, and other diseases. His has been a legacy of death and even today, smoking accounts for 480,000 deaths per year in the U.S., or about 1 out of every 5 deaths. For his contribution to to the death of millions of Americans since his 1953 advertising campaign, John W. Hill is our 6th nominee to the Hall of Shame.

Honorable Mention: Carrie Nation. She was the public face of the Women’s Christian Temperance Union which was the primary driver of the prohibition movement that led to passing the 18th Amendment to the U.S. Constitution outlawing the sale of alcohol on January 16, 1919. She claimed to have a divine vision from God commanding her to destroy bars and saloons. She traveled across the United States with a hatchet that she would use to smash saloon fixtures and liquor bottles. She described herself as “a bulldog running along at the feet of Jesus, barking at what He doesn’t like”. Overall, prohibition did reduce U.S. alcohol consumption by about 30% but instead of drinking low-alcohol percentage beer, people just started drinking bootlegged liquors. These were produced in unregulated stills and were frequently contaminated with methanol. Sellars of illegal spirits would often water them down and then add various poisonous chemicals to mimic the taste and color of liquors. During prohibition, over 1,000 people per year died from consuming tainted liquor. Within 15 years, it became apparent that prohibition did not stop people from drinking, it only created a market for poisonous moonshine. In 1933, the 21st Amendment repealed prohibition.

7. Peter Duesberg, PhD

Athel cb CC BY-SA 4.0 via Wikimedia Commons

In the early 1980’s, gay men were dying from an immunodeficiency syndrome and no one knew why. In 1983, the cause was identified simultaneously by French virologist Luc Montagnier and American virologist Robert Gallo. It was a virus that became known as HIV, or human immunodeficiency virus. Soon after, a lab test was created to diagnose the infection followed by development of AZT, a life-saving anti-viral drug that could treat AIDS. These milestones should have been celebrated by the medical and scientific community as breakthroughs in conquering AIDS. But history has proven that for every disease, there is a disease denialist and for AIDS, the most prominent denialist was Peter Duesberg. He is a Professor of Molecular Biology at the University of California, Berkley who built a successful academic career on his discovery of genes that could cause cancer. He argued that HIV was a harmless virus and that the cause of AIDS was long-term consumption of recreational drugs and anti-viral drugs. Because of his academic credentials, he developed a following of AIDS denialists in the 1990’s. Around the globe, people continued to die of AIDS and by 2000, about 25% of all deaths in South Africa were due to AIDS. Thabo Mbeki, the president of South Africa, convened an AIDS advisory committee to help direct public policy. The committee included Peter Duesberg. Mbeki bought into Duesberg’s AIDS denialism and withheld the use of anti-retroviral drugs in his country. As a result, it is estimated that there were 330,000 preventable deaths from AIDS in South Africa. Duesberg has kept up his claims that HIV does not cause AIDS and as recently as 2012 said on the Joe Rogan podcast that HIV is “one of the most harmless type of viruses we know”. For his actions that contributed to one-third of a million AIDS deaths in South Africa and his inspiration for AIDS denialists everywhere, Peter Duesberg should be nominated for the Public Health Hall of Shame

Honorable Mention: Christine Maggiore. She was diagnosed with HIV in 1992 and became involved in AIDS activism. In 1994, she met Peter Duesberg who convinced her that HIV does not cause AIDS. She came to believe that her own positive HIV test was actually due to an influenza vaccination. She authored a book entitled What If Everything You Thought You Knew about AIDS Was Wrong? and became prominent in the AIDS denialist community. She founded an organization that urged HIV-positive pregnant women to avoid anti-HIV medication. Ironically, she went on to become pregnant herself and refused to take HIV medications. She give birth to a daughter, Eliza Jane, and refused to allow her infant daughter to be tested for HIV. Eliza Jane died of AIDS at age 3 and Christine Maggiore died of AIDS three years later.

8. Jay Dickey

Most of our Hall of Shame nominees are proposed because of their actions that resulted in the proliferation of disease. Although bullets are not a disease, guns have proliferated in the United States just like contagious pathogens. Each year, more than 45,000 Americans die from gunshots and twice that number suffer non-fatal gun injuries. One of the barriers to reducing firearm deaths over the past 25 years has been a law prohibiting research into firearm-related deaths and injuries. The architect of that law was U.S. Representative James Dickey of Arkansas who at the behest of the National Rifle Association, added a clause to the 1996 Omnibus bill that became known as the Dickey Amendment. The amendment stated that “…none of the funds made available for injury prevention and control at the Centers for Disease Control may be used to advocate or promote gun control.” It effectively stopped all research by the CDC into gun-related deaths and injuries. It was not until 2018 that Congress passed a law allowing the CDC to report data on firearm injuries and not until 2020 that Congress allowed funding for firearm injury research by the CDC. By prohibiting the CDC to study gun injuries for 22 years, there was no good data on which to base public policy to reduce firearm injuries and hundreds of thousands of Americans died from guns. Later in his life, Dickey reversed his opinion about gun violence research but he nevertheless deserves inclusion in the Hall of Shame.

Gage Skidmore, CC BY-SA 2.0 via Wikimedia Commons

Honorable mention: Wayne LaPierre. Mr. LaPierre has been the executive vice president and chief executive of the National Rifle Association since 1991. It was he who was the principal lobbyist who influenced Dickey to add the NRAs amendment to the Omnibus bill in 1996. LaPierre has continued to lobby for the proliferation of guns in the United States. Because of his efforts, the U.S. is now the only country in the world with more guns than people.

9. Andrew Wakefield, MD

Bladość, CC BY-SA 4.0, via Wikimedia Commons

As the son of two physicians, it was no surprise that Andrew Wakefield went to medical school at St. Mary’s Medical School in London. He went on to do research in liver and small intestine transplantation and became a member of the Royal College of Surgeons. He developed a hypothesis that the measles virus might be the cause of Crohn’s disease. This evolved into a hypothesis that the measles vaccine might cause Crohn’s disease. Both of these hypotheses were disproven. But Wakefield was undeterred in his quest to link the measles vaccine to some disease. So, he turned to autism and in 1998, he published a paper in The Lancet in which he concluded that 12 children with autism developed “autistic enterocolitis” from the MMR vaccine (measles, mumps, rubella vaccine). He then called for a suspension of childhood vaccination with MMR in a press conference at his hospital. In 2000, he repeated his claims on the CBS news show, 60 Minutes, introducing his theory to American vaccine conspiracy theorists. In 2004, the British public service network Channel 4 reported that before he published his 1998 article about the MMR vaccine, Wakefield submitted a patent for a rival measles vaccine that he said would not cause autism. Presumably, if his vaccine replaced the MMR vaccine worldwide, he would stand to profit enormously. He also started a company to make diagnostic test kits for “autistic enterocolitis” that he predicted would make him $43 million per year. In 2009, his original research was found to be fraudulent and in 2010, The Lancet retracted his 1998 article. Three months later, his medical license was revoked. Dr. Andrew Wakefield’s false claims about the MMR vaccine were the inspiration for other anti-vaxxers. This not only led to thousands of children not receiving appropriate vaccinations but also laid the groundwork for false claims about the COVID-19 vaccines. For his efforts to increase childhood infections, Andrew Wakefield should be included in the Hall of Shame.

Maxlovestoswim, CC BY-SA 4.0 via Wikimedia Commons

Honorable Mention: Robert F. Kennedy, Jr. The son of the late Senator Robert F. (Bobby) Kennedy is an environmental lawyer who makes a living as an anti-vaxxer. Since 2005, he has promoted Andrew Wakefield’s discredited idea that vaccines cause autism. When 2 Samoan infants died in 2018, he opined that the cause of their death was the MMR vaccine. It was later determined that the infants had been errantly injected with a muscle relaxant along with the vaccine and the muscle relaxant was the cause of death. Nevertheless, his views caused many Samoans to forgo the MMR vaccine in their children. As a consequence, in 2019, a measles outbreak resulted in 5,700 infections or 3% of the Samoan population; 83 Samoans died from measles infections. Kennedy became convinced that the preservative thimerosal in vaccines could cause neurological disorders such as autism in children and spread anti-vaccine misinformation. As a result, thousands of pregnant women refused influenza vaccination and thousands of parents refused to allow their children to get flu shots resulting in countless influenza infections and deaths. Many studies have shown that thimerosal in vaccines is safe. He has been a tireless conspiracy theorist and suggested that Anthony Fauci and Bill Gates conspired to prolong the COVID pandemic for financial gain. He promoted the use of ivermectin to treat COVID, despite studies showing that the anti-parasite drug had no effect on COVID infection. Other members of the Kennedy family issued a joint statement about his efforts and said: “…on vaccines he is wrong. And his and others’ work against vaccines is having heartbreaking consequences.”

10. Joseph Mercola, DO

The last of our nominations is for efforts to promote the spread of COVID-19. Dr. Joseph Mercola is an American alternative medicine proponent with a lucrative internet business selling dietary supplements. He stopped seeing patients in 2009 to devote his attention to his internet business and has stated that his net worth is in excess of $100 million. Following in Andrew Wakefield’s shoes, he has been a staunch vaccine critic. It was during the COVID-19 pandemic that Dr. Mercola really hit his stride by promoting unproven supplements (that he sold) as treatments for COVID. He also advocated using inhaled hydrogen peroxide to prevent or cure COVID. An article in the New York Times identified him as the single most influential spreader of COVID misinformation. Becker’s Hospital Review reported that a “Disinformation Dozen” individuals were responsible for 65% of all of the misinformation about COVID and number 1 on that list was Joseph Mercola. His actions have contributed to unfounded fears of effective COVID vaccines and even as of today, one-third of the U.S. population is not fully vaccinated. For his contribution to the perpetuation of the COVID pandemic that has so far killed more than 1 million Americans, Dr. Joseph Mercola is our 10th nominee for induction into the Hall of Shame.

Honorable Mention: Sherri Tenpenny, DO. Occupying the 4th rank in the COVID “Disinformation Dozen” is Ohio’s own Dr. Sherri Tenpenny. She is an anti-vaccine activist who supports the claim that vaccines cause autism. She has written 4 books claiming dangers of vaccines and has stated that COVID vaccines cause death, autoimmune disease, and infertility. She sells these books along with videos and dietary supplements on her website. She stated that COVID-19 vaccines will turn people into “transhumanist cyborgs” and that “by the end of 2022, every fully vaccinated person over the age of 30 may have the equivalent of full-blown vaccine-induced immune suppressed AIDS”. She claims that wearing face masks makes people unhealthy by suppressing their immune systems. In June 2021, she was called by Ohio Republican legislators to testify at the Ohio Statehouse against vaccine mandates. She testified that the COVID vaccines cause people to become magnetized and meanwhile her minions posted on-line videos of spoons stuck to their noses to try to prove her point. Dr. Tenpenny’s claims about magnetism proved to be too far-fetched even for Ohio’s conservative State Representatives and the bill to ban childhood vaccine requirements died in committee.

History is replete with people who have helped to spread disease. Some, like Columbus, did it unknowingly. Some, like Bouquet, did it purposefully. Some, like Comstock, did it in defiance of human nature. Some, like Hill, did it by spreading misinformation. Others, like Mercola, did it in order to make a profit. But whether their actions were intended or unintended, each of our nominees for induction in the  Public Health Hall of Shame helped to promote disease, death, or injury by their actions. The bitter news for the medical profession is that as long as we have people like these 10 inductees, doctors and morticians will never go out of business.

August 9, 2022

Categories
Epidemiology Inpatient Practice Outpatient Practice

Preparing For Monkeypox

Monkeypox is spreading rapidly across the United States. There are steps that every hospital and every medical practice need to take now to protect patients and healthcare workers. As of yesterday, there were 6,326 known cases and undoubtedly considerably more that have gone undiagnosed. Infected patients will be presenting to your hospital, office practice, and emergency department in the next few weeks.

Where did monkeypox come from?

Monkeypox is a type of orthopoxvirus that is related to smallpox. It was first found in monkeys in a Danish research lab in 1958. The virus is not unique to monkeys, however, and has since been found in various mammalian species in Western Africa. Humans have sporadically become infected after contact with infected animals. Although most human cases have been reported in Africa, there have been occasional clusters of cases in other countries over the past 20 years.

One of the most notable clusters occurred in the United States in 2003 when 47 Americans became infected with monkeypox that originated from an infected giant Gambian rat that had been imported from West Africa for sale as an exotic pet. The rat then infected a group of captive prairie dogs that were also sold. Of the 47 cases, all but one person acquired monkeypox directly from an infected animal. In only one case was there human-to-human transmission (from a child to mother).

In July 2021, a traveler from Nigeria was diagnosed with monkeypox in Texas. In November 2021, a second travel-related case was diagnosed in Maryland. The current outbreak began on May 7 2022 when a travel-related case was diagnosed in the United Kingdom. Later that month, cases were diagnosed in Massachusetts and New York. Since that time, the number of cases has been growing exponentially. Because of lack of familiarity with the disease and difficulty in obtaining diagnostic tests, it is likely that most cases initially went undiagnosed and that the true number of U.S. cases is much higher.

How is it spread?

Because the initial cases were reported in gay men, there is a misconception that monkeypox is a sexually-transmitted disease, like syphilis or HIV. It is not. Monkeypox is primarily spread by skin-to-skin contact, similar to MRSA. Thus, the initial cases occurred in gay men not because they had sex with other men but because they had close skin contact with infected men. Although the virus can also be spread by respiratory secretions, it is not as contagious as other respiratory viruses, such as COVID. Therefore, it requires closer and/or more prolonged exposure for airborne transmission. However, because it can be spread by both contact and airborne routes, both contact and airborne isolation is recommended for inpatients. Other points to know about monkeypox transmissibility:

  • It can be transmitted to and from pets
  • Bed linens, clothing, eating utensils, and drinking glasses can be infectious
  • Infected persons remain contagious until scabs have all crusted over and a layer of new skin has developed
  • Usual hospital disinfectants can eliminate the virus
  • The average incubation period is 7 days and persons can be contagious during the incubation period

Signs, symptoms, and diagnosis

As of today, most cases have been in men who have sex with men. However, since monkeypox virus is spread by skin contact (rather than sexual contact), the demographic of infected people is expected to rapidly change in the next few weeks. A person does not have to be gay or to even have sex with another person to become infected. Common signs and symptoms reported in a recent article in the New England Journal of Medicine include:

  • Rash – 95% (with 64% having <10 lesions)
    • Anogenital – 73%
    • Trunk or limbs – 55%
    • Face – 25%
    • Palms or soles – 10%
  • Fever – 62%
  • Lethargy – 41%
  • Myalgia – 31%
  • Headache – 27%
  • Pharyngitis – 21%
  • Lymphadenopathy – 56%

Because 98% of the 528 patients reported in this article were either gay or bisexual men, the incidence of anogenital lesions may be higher than in other patients. The rash is most frequently described as vesiculpustular (53%) but can present as a macular rash (4%), multiple ulcers (19%), or single ulcer (11%). Additional photos of the rash can be found on the CDC website.

Image: UK PHS

The diagnosis is made using swabs of skin lesions – preferably 2 swabs, each from a different lesion. Testing is done by orthopoxviral PCR and results can be available in 2-3 days. Specimen handling procedures can vary from lab to lab so be sure to follow specific instructions from the lab that the sample will be sent to. Until recently, testing was only available through the CDC and results could take 1-2 weeks. Now, testing is available through local health departments as well as several commercial labs making it possible to submit specimens as a regular send-out test from U.S. hospitals. Serology testing is also available through the CDC but the turn around time is 14 days.

Treatment

In cases reported during this outbreak, the mortality rate is low and in most people, the disease is self-limited and of mild-moderate severity. Consequently, to date, only a minority of patients receive anti-viral treatment (5% in the New England Journal of Medicine study). Certain patients are at higher risk of severe disease and these patients should be targeted for treatment:

  1. Those with severe disease (hemorrhagic disease, confluent lesions, sepsis, encephalitis, or other conditions requiring hospitalization)
  2. Immunocompromised persons
  3. Children (particularly those < 8 years old)
  4. Persons with exfoliative skin disorders (atopic dermatitis, psoriasis, etc.)
  5. Pregnant or breast-feeding women
  6. People with monkeypox complications (secondary bacterial skin infection; severe gastroenteritis; bronchopneumonia; etc.)
  7. Involvement of anatomic areas at risk of permanent injury (eyes, mouth, anus, genitalia, etc.)

The treatment of choice is tecovirimat (TPOXX). This drug is currently only available through the Strategic National Stockpile. Physicians have to contact either their state health department or the CDC (770-488-7100 or email at Poxvirus@cdc.gov). The dose is 600 mg PO BID x 14 days given within 30 minutes after a full meal of moderate/high fat. Drug side effects can include headache and nausea. TPOXX may reduce blood levels of midazolam and may increase levels of repaglinide.

Other treatments that may be effective but have less scientific data to support their use include intravenous Vaccinia immune globulin, cidofovir, and brincidofovir.

Vaccination

There are two vaccines available that are effective against monkeypox.Both of these are live virus vaccines (unlike most routine vaccines such as COVID vaccines or flu shots). The JYNNEOS vaccine contains a live non-replicating virus. The ACAM200 vaccine contains a live replicating virus.

JYNNEOS is given as 2 injections with the second dose given 4 weeks after the first dose. Full immune response develops 2 weeks after the second dose. The most common side effects are fatigue, headache, and myalgias. Unlike ACAM200, the JYNNEOS vaccine is not contraindicated in immunocompromised persons, pregnancy, or HIV infection.

The ACAM200 vaccine contains a live replicating Vaccinia virus that is given as a single dose. Because ACAM200 contains a replicating virus, it is contraindicated in immunocompromised persons, HIV infection (regardless of immune status), pregnancy, persons with heart disease, children < 1 year old, persons with eye conditions requiring topical steroids, and persons with a history of exfoliative skin disorders (eczema, atopic dermatitis, etc.). Although most side effects of ACAM200 are mild, 1 out of every 175 persons receiving it develop myocarditis or pericarditis. It takes 4 weeks for maximal immune development after vaccination.

Both vaccines are available from the Strategic National Stockpile. Because of limited supply (particularly of the JYNNEOS vaccine), widespread vaccination of the public and of most healthcare workers is not currently advised. Currently, the CDC only recommends pre-exposure prophylaxis vaccination for people at very high-risk of exposure (primarily laboratory workers performing diagnostic testing for monkeypox). The CDC anticipates expanding the indications for pre-exposure prophylaxis vaccination to broader populations as supplies of the vaccine increase in the future.

Most monkeypox vaccines are currently being given for post-exposure prophylaxis. When given within 4 days of exposure, vaccination can prevent the disease and when given between 4-14 days after exposure, vaccination can reduce the severity of monkeypox infection. Persons who should be prioritized for vaccination include:

  • Known contacts who are identified by public health via case investigation, contact tracing, and risk exposure assessments
  • Persons with a sexual partner in the past 14 days who was diagnosed with monkeypox
  • Persons who have had multiple sexual partners in the past 14 days in a jurisdiction with known monkeypox
  • Healthcare workers with a high risk exposure such as:
    • Unprotected contact with skin, lesions, or bodily fluids of a patient with monkeypox
    • Aerosol-generating procedures without N-95 mask and eye protection

Healthcare workers with an intermediate risk exposure should be offered post-exposure vaccination on a case-by-case basis and after discussion of the risks and benefits with the exposed healthcare worker. Intermediate risk exposures include: (1) being within 6 ft of an infected unmasked patient for more than 3 hours when the healthcare worker was not wearing a mask and (2) contact with patient’s clothing, skin lesions, or soiled linens while wearing gloves but not wearing a gown.

Healthcare workers with a low risk exposure generally do not require post-exposure vaccination. Low risk exposures include: (1) entering an infected patient’s room without wearing eye protection, (2) being in a room with an infected patient while wearing gown, gloves, eye protection and at least a surgical mask or (3) being within 6 feet of an unmasked patient for less than 3 hours without wearing at minimum, a surgical mask. Additional information about managing exposed healthcare workers can be found on the CDC website.

Isolation recommendations for infected outpatients

The vast majority of people infected with monkeypox can be treated as an outpatient. In order to control the spread of monkeypox in the community, it is essential that infected persons adhere to proper isolation procedures at home for the duration of infectivity. Infected persons remain contagious for 2-4 weeks. Isolation can be discontinued when until all symptoms have resolved, including full healing of the rash with formation of a fresh layer of skin in areas of vesicles and ulcers. Isolation practices include:

  • Remain in the home with no contact with other people
  • Avoid close physical contact, including sexual and/or close intimate contact, with other people.
  • Avoid sharing utensils or cups. Items should be cleaned and disinfected before use by others.
  • Do not share items that will be worn or handled with other people or animals.
  • Wash hands often with soap and water or use an alcohol-based hand sanitizer, especially after direct contact with the rash.
  • Avoid contact with pets
  • Launder and disinfect items that have been worn or handled and that have been touched by a lesion
  • Do not dry dust or sweep as this may spread the virus
  • Do not wear contact lenses (because of risk of spreading the virus to the eyes)
  • Clean and disinfect surfaces with an Environmental Protection Agency-registered disinfectant. If other household members are responsible for cleaning, they should wear a medical mask and disposable gloves, at a minimum
  • If the infected person must leave home for medical care or for an emergency, cover the lesions, wear a well-fitting mask, and avoid public transportation

Infection control in the outpatient office

Although not as contagious as COVID, there is still a risk of an outpatient with monkeypox infecting other patients or healthcare workers. All employees of outpatient medical practices need to be familiar with monkeypox infection control practices to minimize the risk of spreading the infection. Specific measures include:

  • Utilize telemedicine for patients known or suspected to have monkeypox
  • If using pre-registration procedures in advance of patients arrival to the office, include questions about monkeypox signs and symptoms
  • Place patients with known or suspected infection in a private exam room with the door closed. These patients should be escorted from the building entrance directly to the exam room and should not wait in a waiting area
  • Have patients with known or suspected infection wear a surgical face mask with areas of skin rash covered
  • Healthcare workers entering an exam room of a patient with known or suspected infection should wear a disposable gown, gloves, eye protection, and an N-95 mask
  • Use disposable paper exam table drapes and patient gowns. Dispose of these materials using medical waste trash bags and do not shake out gowns or drapes
  • When the patient leaves, sanitize the room surfaces. Most standard hospital disinfectants will suffice. A list of cleaning products can be found on the Environmental Protection Agency website.

Infection control in the hospital

Only a small minority of patients will require admission to the hospital. Some of the indications for admission include pain management (such as severe anorectal pain), soft-tissue superinfection, pharyngitis limiting oral intake, eye lesions, acute kidney injury, myocarditis, and public health infection-control purposes. Infection control measures for hospitalized patients include:

  • Place patients with known or suspected infection in a private room with private bathroom and with the hallway door closed (negative airflow is not required)
  • Transport and movement of the patient outside of the room should be limited to medically essential purposes
  • When patients must be transported outside of their room, they should wear a medical mask and have any exposed skin lesions covered with a sheet or gown
  • Healthcare workers should wear a disposable gown, gloves, eye protection, and an N-95 mask
  • If aerosol-generating procedures are to be performed (e.g., intubation or bronchoscopy), use an airborne isolation room
  • Environmental services such as dry dusting, sweeping, or vacuuming should be avoided in rooms housing infected patients
  • Disposables such as paper towels should be disposed of using medical waste trash bags
  • Use surface cleaning products that are believed to be effective for emerging viral pathogens  (listed on the Environmental Protection Agency website)
  • Do not shake soiled linen, towels, and gowns. Soiled items should be enclosed in a proper laundry bag for transport to the laundry and staff handling laundry from infected patients should wear proper personal protective equipment as recommended by the CDC
  • Visitors should be limited to those essential for the patient’s care and wellbeing

Don’t think of monkeypox as a sexually-transmitted disease

Because the current outbreak has so far primarily affected men who have sex with men, monkeypox has developed a mistaken stigmata of being a sexually transmitted disease. It is important that we educate our patients and our co-workers that it is not necessary to have sex with someone to become infected with monkeypox. Measures that prevent spread of HIV and syphilis will not work with monkeypox. Abstinence will not stop it. Condoms will not stop it.

One of our best weapons against monkeypox is education.

August 3, 2022

Categories
Epidemiology

Do Republicans Live Longer Than Democrats?

Who lives longer, Republicans or Democrats? The answer may surprise you. Many people hold the stereotype of Republicans being wealthy, being better educated, and having better access to healthcare. Democrats often hold the stereotype of being working class, poor, and wanting government healthcare handouts. Intuitively, this would translate to Republicans being healthier and living longer than Democrats.

Summary Points:

  • Health metrics correlate with the partisan index
  • People living in Republican-leaning states have a significantly shorter life expectancy than people living in Democrat-leaning states
  • Republican states have a higher COVID death rate, higher prevalence of obesity, and higher prevalence of smoking than Democrat-leaning states
  • Residents of Democrat-leaning states have a higher annual household income than residents of Republican-leaning states

 

Historically, Republicans were found to be healthier than Democrats. In a 2009 article from the International Journal of Epidemiology, investigators analyzed data from the 1972 – 2006 General Social Surveys and found that survey respondents who identified as Republican had better self-reported health and were less likely than Democrats to be smokers. Similarly, a 2015 article from the journal Political Research Quarterly found that people who identified as having good health were more likely to vote Republican in the preceding presidential election.

A more recent study in the May 2022 edition of the British Medical Journal found that the association of political party with health may be reversing. This study compared the voting patterns of individual U.S. counties in the 5 presidential elections between 2000 to 2019 with the changes in the mortality rates in each of those counties during the same time period. The results indicated that counties voting Democratic had greater improvements in mortality rates than counties voting Republican. Moreover, the separation between improved mortality rates and political party voting only became apparent after 2008. This suggests that there has been a change over the past 15 years with Democrats now becoming the healthier of the two political parties.

It turns out that determining how political party affiliation affects life expectancy and other health metrics is quite difficult. Nowhere on a death certificate is there an entry for the doctor to  record political party. Because our voting choices are confidential, there is no way to do a public record search for how dead Americans voted in the past Therefore, the only way to study political party affiliation and health outcomes is by correlation studies that look at voting patterns and health metrics of different geographic locations.

The Cook Partisan Voting Index

In 1997, a new method of determining political affiliation was developed called the Cook Partisan Voting Index. For the past 25 years, the index has been used to determine how strongly a congressional district or a state leans toward the Republican party or the Democratic Party. The index is based on voting patterns in the previous two presidential elections. The most recent data is based on voting in the 2016 and 2020 elections. The higher the number, the more strongly a state leans towards one political party.

In this table, Democratic-leaning states are in blue and are denoted with negative numbers; the more negative the number, the more the state leans Democratic. Republican-leaning states are in red and denoted with positive numbers; the higher the number, the more the state leans Republican. The most strongly Republican state is Wyoming and the most strongly Democratic states are Vermont and Hawaii. Two states (Nevada and New Hampshire) are equally split between Republican and Democratic parties and they are denoted in purple. The use of negative numbers for Democratic states and positive numbers for Republican states in this table is purely to facilitate statistical comparisons.

The Cook Partisan Index also reports the political leaning by individual congressional district. The most Democratic district is California’s 12th (Oakland area) and the most Republican district is Alabama’s 4th (rural northern Alabama).

Party affiliation and life expectancy

If we use the Cook Partisan Voting Index as a marker for party affiliation, then we can compare states with a high Republican index to states with a high Democratic index and see how those voting patterns correlate with health metrics. Life expectancy is one of the simplest of these metrics. Life expectancy can be measured in several ways. The most common measurements are (1) life expectancy from birth, (2) life expectancy from age 18, and (3) life expectancy from age 65. Each of these measurements has advantages and disadvantages.

Life expectancy from birth will be lower if there is a high infant and childhood mortality rate. Life expectancy from age 18 eliminates infant mortality but will be affected by gun-related deaths, drug overdoses, and motor vehicle deaths that are more common in young adults. Life expectancy from age 65 eliminates those young adulthood causes of death and is more affected by life-long unhealthy habits such as smoking, obesity, and alcohol abuse. For this analysis, let’s use life expectancy from birth since it incorporates all of the variables that can affect mortality from infancy through early adulthood and into older age.

In comparing the Cook Partisan Voting Index to life expectancy from birth, many people would suspect that Republicans would have a longer life expectancy than Democrats. However, just the opposite is true. People living in Democratic party states live longer than those in Republican party states. States that most strongly leaned Democrat had the longest life expectancy.

Overall, life expectancy in states found to be Democratic by the Cook Partisan Voting Index had a mean life expectancy of 79.6 years whereas the mean life expectancy in Republican states was 77.4 years (p < 0.001). This represents an average 2.2 year longer life expectancy in Democrat-leaning states.

Party affiliation and smoking

The finding of longer life expectancy in states that lean Democratic indicates that there has been a change in political party affiliation and health measures compared to older studies that showed Republicans were generally healthier than Democrats. One of the strongest predictors of life expectancy is smoking. In the past, Republicans were less likely to be smokers than Democrats. Could a change in the prevalence of smoking among people voting Republican versus Democrat be partially responsible for the change in life expectancy?

To answer this question, let’s examine the association between the Cook Partisan Voting Index and smoking rates by state. Each year, the Centers for Disease Control reports the percentage of adults in each state who smoke. Overall, the percentage of all Americans who smoke has been steadily falling since the mid-1960’s.

However, there are wide differences in smoking patterns between different states, ranging from a low of 7.9% of adults smoking in Utah to a high of 23.8% of adults smoking in West Virginia. Overall, states that lean Republican have a higher prevalence of smoking than states that lean Democratic (r = 0.64). The average adult smoking rate was 13.7% in Democrat states and 17.8% in Republican states (p < 0.001).

Party affiliation and obesity

A second health demographic that has changed over the past several decades is obesity. Overall, Americans have been becoming more obese each year. The CDC reports that the rate of obesity (BMI > 30) has increased from 30.5% in 2000 to 42.4% in 2018. Similarly, the rate of severe obesity (BMI > 40) has increased from 4.7% to 9.2%. These statistics are from the National Health and Nutrition Survey (NHANES) which is based face-to-face surveys performed in participating American’s homes by a physician and other health professionals.

As with smoking, there are substantial differences in the rate of obesity among different states. The Behavioral Risk Factor Surveillance System (BRFSS) reports obesity rates by state based on adult self-reported information from phone surveys. These self-reported obesity data differ from the NHANES data with a lower overall incidence of obesity than NHANES. This difference has been attributed to differences in how the data are obtained (in-person interview versus phone survey). The state with the highest rate of obesity is West Virginia and the state with the lowest rate of obesity is Colorado. Based on the BRFSS data, states that lean Democratic have an adult obesity prevalence of 29.1% and states that lean Republican have an adult obesity prevalence of 34.3% (p < 0.001)

Party affiliation and COVID mortality

One of the major causes of death in the United States in the past two years has been COVID-19. So far, 1,024,611 Americans are known to have died from COVID and many more have likely died from COVID or COVID complications that were not listed on death certificates. A study published last month in JAMA Internal Medicine found that in 2021, COVID was the 4th leading cause of death in Americans age 25-34 (after accidents, suicide, and assault), the number 1 cause of death in Americans age 45-54, and the 3rd leading cause of death in Americans over age 65 (after cancer and heart disease).

As noted in a previous post, there are significant differences in how Republicans and Democrats fared during the COVID-19 pandemic with residents in Democratic states more likely to be vaccinated against COVID, less likely to become infected with COVID, and less likely to die from COVID than residents in Republican states. By comparing the Cook Partisan Voting Index to the death rate of COVID for each state, we again find that the  there is an association between party affiliation and death from COVID. Overall, 260 people per 100,000 population have died from COVID in Democrat-leaning states whereas 331 per 100,000 died from COVID in Republican-leaning states (p = 0.005).

Party affiliation and personal income

As noted earlier, historically Republicans had a higher self-reported annual income than Democrats. The stereotypical Republican was a capitalism-supporting business owner and the stereotypical Democrat was a blue collar worker who belonged to a union. Personal income has been shown to affect health outcomes with wealthier persons having better health and poorer persons having worse health. Could a change in income demographics between Republicans and Democrats be partially responsible of the shorter life expectancy of residents of Republican states?

By comparing household income to the Cook Partisan Voting Index, we find that residents of states leaning Democratic have a higher annual income than residents of states leaning Republican. The average income in Democratic-leaning sates was $71,264 and the average come in Republican-leaning states was $59,108 (p < 0.001).

Money is only worth what you can buy with it. The highest income states are also the states with the highest cost of living so the above analysis man not necessarily equate to the purchasing power of each household. Nevertheless, it appears that voters favoring Republicans in the last two presidential elections have a different relative annual income than voters favoring Republicans in previous presidential elections. Residents of states who have recently favored Republicans have a lower income than those favoring Democrats.

Today’s Republicans are not your parent’s Republicans

A generation ago, compared to Democrats, Republicans were wealthier, healthier, and less likely to smoke. Today’s Republicans have a lower income, are more obese, are more likely to smoke, and are more likely to die young than Democrats. This generational reversal in the relationship between party affiliation and health metrics has implications for future healthcare utilization.

For example, given a 2.2 year longer life expectancy, residents of Democrat-leaning states would be expected to utilize 18% more Medicare and Social Security benefits than residents of Republican-leaning states (assuming Medicare and Social Security benefits starting at age 65). The longer a person lives, the more elections that person can vote in. The results imply that people voting Democrat will vote in an average of 2 more annual elections over the course of their lifetimes than those who vote Republican.

Obesity is associated with other health conditions such as diabetes, hypertension, sleep apnea, and arthritis. This could indicate that people voting Republican are more likely to have these conditions in addition to being more likely to be smokers. The result could be a higher incidence of disability among people voting Republican than among people voting Democrat.

It seems paradoxical that people living in states that lean toward the Democratic party have higher incomes and thus are in higher income tax brackets and pay more in income tax than people living in states that lean toward the Republican party. Democrats are often characterized as favoring higher taxes whereas Republicans are generally characterized as favoring tax cuts.

We will not fully know all of the healthcare implications for the apparent change in voter demographics for several years. However, it is likely that the evolving differences in health metrics between states that vote Republican and states that vote Democrat will result in very different approaches to healthcare policy.

August 1, 2022

Categories
Epidemiology Outpatient Practice

Abortion And The Five Whys

If you know four women, then statistically, one of them has had an abortion. The current Supreme Court recently overturned the opinion of a previous Supreme Court and now permits states (or the U.S. Congress) to make abortion illegal. By applying the “5 Whys” approach to abortion, we can learn the root causes of abortion and how to reduce the number of abortions without criminalizing abortion. We can also uncover the hidden costs of abortion bans.

The five Whys

The 5 Whys originated in the early 1900’s in Japan as a method to improve textile production. What does 100-year-old Japanese loom manufacturing have to do with abortion? As it turns out, a lot. Sakichi Toyoda was a Japanese industrialist who invented an automatic power loom that at the time was the most advanced weaving device in the world. He went on to found Toyota Industries, the manufacturer of Toyota automobiles. To address quality issues in manufacturing, he created the “Five Whys” approach. This utilized asking a series of five “Why” questions to determine the cause-and-effect relationship with any manufacturing process. This approach has been incorporated in Kaizen, lean manufacturing, and Six Sigma. It is also a key component of root-cause analysis that we use in hospital quality improvement today.

An example of the Five Whys is as follows: A hospital medical director learns from the infection control department that there have been a cluster of Clostridium difficile infections in certain rooms in the intensive care unit. To understand the root cause, the medical director asks a series of Why questions:

So, the solution to the hospital’s C. difficile problem was not to close ICU rooms or fire the housekeeping employee. The solution was for the purchasing department to buy the correct spray dispensers used with hypochlorite disinfectants. If all 5 of the “Why” questions had not been asked, the root cause would never have been determined and the C. difficile outbreak would not have been eliminated.

Asking 5 Whys can sometimes be overly simplistic. In the C. difficile example, there is one root cause identified at the fifth Why. Sometimes the root cause can be found at the second Why. Sometimes it takes 6 Whys. And sometimes, there are multiple root causes that can be identified at several levels of the Whys. The point is that it is necessary to continue to ask “Why” until the root causes are all identified.

Our country has taken a superficial approach to the issue of abortion. We have let our emotions stop at the first “Why” and have not done an adequate root-cause analysis of abortion. In half of our nation’s states, politicians have determined that many women are getting abortions and asked the first Why. The answer that they found is that there are doctors willing to perform abortions. Their solution has been to criminalize abortion. The problem is that they have not asked the other “Whys”. With abortion, the root causes are complex and can be found at each level of Whys.

The demographics of abortion in the U.S.

Before we can apply the 5 Whys to the issue of abortion, we first must examine the demographics of abortion. The World Health Organization reports that worldwide, about 73 million abortions are performed each year. This equates to 29% of all pregnancies ending in abortion. In the United States, the Centers for Disease Control reports that there were 629,898 abortions performed in 2019 (the latest year data is available). The Guttmacher Institute (which uses a more thorough accounting method) reports that there were 930,160 abortions performed in 2020. This works out to 1 out of 5 pregnancies in the United States ending in an induced abortion. The U.S. accounts for about 1.3% of abortions worldwide. Additional epidemiological facts include:

  • 24% of women under age 45 years old have had an abortion.
  • The most common reason for having an abortion is not being ready to have a child (25%), followed by unable to afford a child (23%), done having children (19%), not wanting to be a single mother (8%), not mature enough to raise a child (7%), interference with education or career (4%), maternal health problems (4%), fetal abnormalities (3%), and rape (< 0.5%).
  • Most women undergoing abortion are in their twenties: 34% of abortions are in women age 20-24 and 27% of abortions are in women age 25-29.
  • 12% of abortions are performed in teenagers with 3.2% under age 18.
  • Black and Hispanic women have disproportionately more abortions than White women. Black women account for 28% of abortions but Blacks make up 13% of the U.S. population. Hispanic women account for 25% of abortions but Hispanics make up 19% of the population. White women account for 39% of abortions but Whites make up 76% of the population.
  • 38% of women undergoing abortion reported no religious affiliation; 24% are Catholic; 17% are mainline Protestant; and 13% are evangelical Protestant.
  • 86% of women undergoing abortion are unmarried and 60% already have at least one child.
  • 75% of women undergoing abortion are low income: 49% live below the Federal poverty level and an additional 26% are at 100% – 199% of the Federal poverty level.
  • 53% of women paid for their abortion out-of-pocket. The average cost of a surgical abortion is $508 and of a medication-induced abortion is $535.
  • 51% of women were using birth control in the month that they became pregnant: 24% were using condoms and 13% were using oral contraceptive pills.
  • 88% of abortions occur in the first 3 months of pregnancy and 67% occur in the first 2 months of pregnancy.
  • 54% of abortions are currently performed by medication (mifepristone and misoprostol).
  • The largest number of abortions were performed in Texas, California, New York and California, however, these are also the states with the highest populations.
  • The states with the highest rates of abortion per 100,000 population are New York, New Jersey, and Maryland.

The demographics of women who undergo abortion is remarkably similar to the demographics of infant mortality. The United States has one of the highest infant mortality rates in the world – we rank 33rd out of 36 OECD countries with only Chile, Turkey, and Mexico having higher infant mortality rates. In states where women no longer have access to abortion, it follows that infant mortality rates will rise. Many of the states poised to criminalize abortion (with either outright bans or 6-week laws) already have very high infant mortality rates:

Applying the 5 Whys to abortion

Once we understand the demographics of abortion in the United States, we can apply the 5 Whys:

  1. Why are there abortions in the U.S.?
    1. Answer: because doctors performed abortions.
  2. Why are doctors performing abortions?
    1. Answer: because a lot of women requested them due to unwanted pregnancies.
  3. Why did women have unwanted pregnancies?
    1. Answer: because effective birth control was not used.
  4. Why wasn’t effective birth control used?
    1. Answer: most commonly because effective birth control methods were too costly and there were cultural barriers to their use.
  5. Why were there cultural barriers to birth control?
    1. Answer: because men and women were not adequately educated about birth control before they had sex.

If we stop after the first why, then the solution to humans having so many abortions is to make abortion illegal and prosecute doctors who perform abortion. But this will ultimately fail. History has showed us that in the past, when abortion was illegal, women still found ways to have abortions, in other words, making it illegal will not make abortions go away. This is especially true today since prior to 10 weeks gestation, a 2-pill form of abortion is safe and effective (mifepristone and misoprostol). Currently, these drugs are approved by the FDA, are readily available, and account for the majority of abortions in the U.S. Even if a future conservative U.S. Congress bans their use, these drugs will continue to be available as street drugs and from international sources – if the war on drugs cannot prevent a marijuana joint from being smuggled into the country for street sale, how can one expect the government to prevent 2 small pills from being smuggled in?

If we stop with the second why, then the solution is to prevent women from having intercourse. There are 3 main instincts that a species must have to keep from becoming extinct: (1) an instinct to eat, (2) an instinct to keep from being eaten, and (3) an instinct to procreate. To stop Homo sapiens from having sex is to somehow overcome one of the most powerful instincts that our species has had for the past 300,000 years and led to us being the dominant species on the planet. It just won’t work. We can pass laws and we can invoke religious decrees but neither is more powerful than instincts embedded in our genes.

At the third why, we find that about half of abortions were in pregnancies where no birth control method was used. In another 37%, inferior birth control methods were used (condoms and birth control pills). Condoms are notoriously unreliable and it is way too difficult for any person to remember to take a birth control pill every single morning for years at a time. IUDs are far more reliable but not all women can tolerate them. Vasectomies are even more effective but that would require men to take more responsibility than many of them want to – I’ve fought an uphill (and usually unsuccessful) battle with many husbands of my patients for who I prescribed teratogenic medications for their advanced lung disease and in who an unwanted pregnancy would likely result in the wife’s death or in severe fetal deformity. However, I suspect that if men had to choose for themselves between the discomfort of a vasectomy versus the discomfort of pregnancy, labor, and delivery, 100% of them would take the vasectomy.

At the fourth why, we find barriers to the use of birth control in the way of cost and cultural discouragement. The cost of contraception is directly proportional to the effectiveness of contraception. Calendar watching is free but is miserably ineffective. Condoms cost about a dollar each but are not much more effective. Nor are diaphragms which are about $25 each. Birth control pills cost about $180 per year and an IUD costs about $800 (but IUDs can last 12 years resulting in a depreciated cost of $65 per year). A hormonal implant costs about $1,000 and lasts for 3 years. A vasectomy costs about $1,000 and a tubal ligation costs about $6,000 with both giving a lifetime of highly effective birth control. The over the counter morning-after pill, Plan B (levonorgestrel), costs $45 and is about 85% effective. Because the majority of women undergoing abortion are low income and a large number have no health insurance, birth control costs are a major contribution to the number of abortions performed in the U.S. The sad reality is that even the most expensive form of birth control is less expensive than the average $8,800 cost to deliver a baby, and that does not even include the indirect cost of maternity leave and raising the child if not put up for adoption.

Even when men and women have health insurance or can afford to buy contraception out of pocket, there are numerous cultural barriers to using contraception. For example, the Catholic Church forbids its members to use any form of contraception and considers contraception to be a sin. The underuse of contraception is perhaps the reason why Catholics have disproportionately more abortions than women of other religions – 24% of women who undergo abortion are Catholic whereas only 21% of the American population is Catholic. Parenthetically, it is notable that 7 of the 9 current Supreme Court Justices are Catholic or were raised Catholic; all 6 of the justices voting to overturn Roe v. Wade are Catholic. Old-Order Amish communities also forbid contraception. Most other religions permit the use of contraception but usually only within the context of marriage.

At the fifth why, we find lack of education. In most states, sex education curricula decisions are left to local school boards. Consequently, there is enormous variation in what is taught in different school districts. Children in many religious-based schools get no education about contraception and children who are home-schooled may get no formal sex education at all. The Centers for Disease Control recommends that children be taught a minimum of 20 sex education topics but fewer than half of American high schools teach all 20 of these. The Guttmacher Institute reports that U.S. adolescents in 2019 received less sex education than in 1995. In short, our educational system, both public and private has failed in sex education and this failure is an important contribution to the number of abortions in the U.S.

So, how do we reduce the number of U.S. abortions?

First, we will never eliminate all abortions nor should abortions be illegal. As a medical student, I assisted in the delivery room with a 12-year-old who was delivering a baby… no 12-year-old should ever have to deliver a baby. Forcing a child, a rape victim, or an incest victim to carry and deliver a baby is truly punishing the victim. In addition to these situations, there will always be unplanned sexual encounters and contraception method failures.

Infrequently entered into the discussion is that in the half century since Roe v. Wade was decided, there have been enormous advances in neonatology that have saved the lives of thousands of children who would have previously died in infancy. However, these same advances have also allowed medical science to keep on life support those with severe fetal deformities and chromosomal abnormalities with no reasonable chance of ever having normal cognitive development or independent function. Fifty years ago, in the pre-Roe era, they would have died within minutes or hours of delivery. These fetal abnormalities can largely be detected by a combination of ultrasound and maternal serum screening tests, neither of which existed in the pre-Roe era. Currently, serious fetal abnormalities account for up to 3% of all abortions. With no access to abortion, these fetuses will now be born and can live for weeks, months, and sometimes even years requiring ventilators, feeding tubes, and 24-hour care. The CDC reported that the annual inpatient hospitalization costs of severe birth defects was $22.9 billion in 2013. That number will be considerably higher when these fetuses can no longer be legally aborted.

In all of these situations, an unwanted pregnancy puts unwanted health and financial demands on the woman. It also places her at a competitive disadvantage in the workplace that can result in gender income disparities and barriers to professional advancement. Adoption is often offered as the solution to unwanted pregnancies but the reality is that most women do not put the child of an unintended pregnancy up for adoption. There are approximately 2.8 million unintended pregnancies in the U.S. every year. The National Council for Adoption reports that in 2020, there were 55,659 public adoptions in the U.S. The USDA estimates that the cost to raise a child to age 18 is $284,000 and this does not include the indirect cost of career development impediment faced by the (often single) mother raising that child.  It may take 2 people to create a pregnancy but it is the woman who pays most of these costs, not the man. Simply making abortions illegal does nothing to address this and in fact, makes it considerably worse.

We can (and should) reduce the number of abortions in the United States. If she didn’t have to have an abortion, no woman would want to have an abortion – it’s not like it is a fun experience. No woman says “What should I do to have fun this weekend? Maybe go to a concert, or go see a movie, or maybe get an abortion?” America’s abortion problem is an unwanted pregnancy problem. The most effective way to reduce the number of abortions is to reduce the number of unwanted pregnancies and for that, we need to turn back to the five Whys and the following conclusions:

  1. We cannot rely on the fantasy of abstinence and chastity. $3.2 billion in child sex lawsuit settlements says that this didn’t work for a lot of Catholic priests so why should it work for everyone else?
  2. We need to improve and standardize sex education and contraception education in our private schools, public schools, and home schools.
  3. Birth control (including vasectomy) should be free for all Americans – 135 women could have an IUD for a year for the same taxpayer cost of one woman on Medicaid delivering an unwanted pregnancy.
  4. We cannot base laws and social expectations founded on unrealistic religious doctrines that defy the most basic elements of human nature.

What do the 5 Whys tell us about the hidden costs of abortion bans?

On the day that the current Supreme Court overturned Roe v. Wade, abortion became completely illegal or illegal after 6-weeks gestation in many states and undoubtedly will become illegal in more states in the months to come. There are hidden costs to everything and by looking at the 5 Whys of abortion, we must be prepared to pay for the hidden costs of abortion bans:

  1. Localities with laws making abortion illegal must also have counterbalancing laws mandating paid maternity leave, government-paid maternal healthcare, and government-paid childcare. Anything less is state-sponsored victimization of women.
  2. Localities with laws making abortion illegal must also have laws providing for the post-delivery healthcare costs of fetuses that have severe fetal deformities and chromosomal abnormalities.
  3. Localities with laws making abortion illegal after 6 weeks of gestation must also have laws providing unlimited free pregnancy testing so that pregnancy can realistically be identified before 6 weeks.
  4. Localities with laws making abortion illegal must be prepared for an increase in infant mortality and should begin investment in programs to reduce infant mortality.

I’m like most Americans

Being retired gives me a freedom that I never had when I was a practicing physician. I no longer have to withhold my opinions about controversial issues for fear of offending my patients who hold different viewpoints or fear of incurring the wrath of deans, department chairs, and hospital CEOs. I can now freely say what I believe.

Abortion is subject to basic economic supply and demand principles like most everything else in life. Making abortion illegal only addresses the supply side and does nothing for the demand side. Focusing only on supply was ineffective with Prohibition in the 1920’s and has been ineffective with marijuana laws today. Economics tells us that reducing supply of a product or service without reducing demand will only increase the price of that product or service – reducing supply alone does not eliminate demand.

When it comes to abortion, I believe it should be legal. But I also believe that we do too many abortions. In short, I’m like most Americans.

The way to reduce demand for abortions is to reduce unwanted pregnancies. By doing a root cause analysis of abortion in the United States using the 5 Whys, we can identify how to reduce the number of abortions by reducing unwanted pregnancies. The 5 Whys also uncover the unintended consequences and hidden costs of abortion bans. Our societal goal should be to make abortions fewer and not to make abortions felonies.

July 2, 2022

Categories
Epidemiology

Grading Each State’s COVID Response

Sometime next month, the United States will surpass one million reported deaths from COVID-19. So, how did your state compare in combating the pandemic? I graded each state by four measures: (1) total cases per 100,000 population, (2) total deaths per 100,000 population, (3) seroprevalence, and (4) percent of the population fully vaccinated. I then created a composite score using all four metrics to give an overall grade for every state plus Washington DC and Puerto Rico. Grades for each metric from A+ through F were assigned with 4 states getting any given grade.

  1. Total cases per 100,000 population. These are the cases reported by state health departments to the CDC as of April 28, 2022. The higher the number, the more documented cases occurred since January 2020 per capita. This number does not reflect the true number of cases since many people test positive with home test kits that are not reported to their health departments and many patients with mild or no symptoms do not get tested.
    • Grade A+ states: Puerto Rico, Oregon, Maryland, Hawaii,
    • Grade F states: Alaska, Rhode Island, North Dakota, Tennessee
  2. Total deaths per 100,000 population. These are the deaths reported by state health departments to the CDC as of April 28, 2022. The higher the number, the more deaths occurred since January 2020 per capita. Because the deaths from COVID are only counted if COVID is listed as a cause of death on the death certificate, these numbers are undoubtedly also an underestimate since COVID may not be listed on a death certificate if a person did not have a COVID test before dying or if a person died at home and no information about symptoms was available to the physician signing the death certificate.
    • Grade A+ states:Vermont, Hawaii, Puerto Rico, Utah
    • Grade F states: Mississippi, Arizona, Alabama, Tennessee
  3. Seroprevalence. This is from the February Nationwide Antibody Seroprevalence Survey. In this study, left-over blood samples from blood drawn from clinical labs are tested for antibodies against the COVID-19 virus. Notably, the specific antibodies tested for are those generated from actual infection and do not result from vaccination. The higher the number, the greater the percentage of the state’s population has actually had a true COVID-19 infection (of note, there is no recent data for North Dakota; because there was no data for Montana and New Hampshire from the February study, data from the January study was used for these two states). Overall, this study estimates that 57.5% of Americans have had a COVID infection. However, because antibody levels decline over time, many people who have had an infection many months previously will no longer have antibodies. Therefore, these numbers likely underestimate the actual percentage of the population that has had an infection.
    • Grade A+ states: Vermont, New Hampshire, Hawaii, Puerto Rico,
    • Grade F states: Iowa, Texas, Mississippi
  4. Percent of the population fully vaccinated. This is the percentage of people in each state that have received at least 2 doses of the Pfizer vaccine, 2 doses of the Moderna vaccine, or 1 dose of the Johnson & Johnson vaccine as reported by the CDC. This percentage reflects the entire population of the state, including young children who are not yet eligible to receive vaccinations and therefore the percentage of adults fully vaccinated will be higher.
    • Grade A+ states: Puerto Rico, Rhode Island, Vermont, Maine
    • Grade F states: Alabama, Wyoming, Mississippi, Louisiana
  5. Overall score. For each of the above four metrics, states (plus Washington D.C. and Puerto Rico) were ranked 1 through 52. The overall score was calculated by adding the ranks for each of the four metric and determining the average of those 4 numbers. For North Dakota, there is no data available for the seroprevalence study so the overall score was calculated by the average of the other 3 metrics.
    • Grade A+ states: Puerto Rico, Vermont, Hawaii, Maine
    • Grade F states: Tennessee, Mississippi, Arkansas, Alabama

Here are the scores for each state

Alabama

  • Case Rate per 100,000 = 26,524; grade: C-
  • Death Rate per 100,000 = 398; grade: F
  • Seroprevalence = 66.0%; grade: D
  • Percent Fully Vaccinated = 51.1%; grade: F
  • Overall Rank = 49; grade: F

Alaska

  • Case Rate per 100,000 = 33,479; grade: F
  • Death Rate per 100,000 = 166; grade: A
  • Seroprevalence = 61.0%; grade: C
  • Percent Fully Vaccinated = 62.3%; grade: C+
  • Overall Rank = 26; grade: C+

Arizona

  • Case Rate per 100,000 = 27,773; grade: D
  • Death Rate per 100,000 = 411; grade: F
  • Seroprevalence = 63.0%; grade: C-
  • Percent Fully Vaccinated = 61.5%; grade: C
  • Overall Rank = 48; grade: D-

Arkansas

  • Case Rate per 100,000 = 27,683; grade: D
  • Death Rate per 100,000 = 377; grade: D-
  • Seroprevalence = 64.0%; grade: D+
  • Percent Fully Vaccinated = 54.4%; grade: D-
  • Overall Rank = 50; grade: F

California

  • Case Rate per 100,000 = 23,281; grade: B+
  • Death Rate per 100,000 = 226; grade: B+
  • Seroprevalence = 55.5%; grade: B
  • Percent Fully Vaccinated = 72.0%; grade: B+
  • Overall Rank = 12; grade: A-

Colorado

  • Case Rate per 100,000 = 23,979; grade: B
  • Death Rate per 100,000 = 210; grade: A-
  • Seroprevalence = 47.9%; grade: A-
  • Percent Fully Vaccinated = 70.2%; grade: B
  • Overall Rank = 10; grade: A-

Connecticut

  • Case Rate per 100,000 = 21,204; grade: A-
  • Death Rate per 100,000 = 303; grade: C+
  • Seroprevalence = 44.4%; grade: A
  • Percent Fully Vaccinated = 79.2%; grade: A
  • Overall Rank = 11; grade: A-

Delaware

  • Case Rate per 100,000 = 26,902; grade: D+
  • Death Rate per 100,000 = 298; grade: C+
  • Seroprevalence = 54.0%; grade: B+
  • Percent Fully Vaccinated = 69.1%; grade: B
  • Overall Rank = 23; grade: B-

Washington D.C.

  • Case Rate per 100,000 = 20,112; grade: A-
  • Death Rate per 100,000 = 189; grade: A-
  • Seroprevalence = 63.6%; grade: D+
  • Percent Fully Vaccinated = 74.1%; grade: A-
  • Overall Rank = 13; grade: B+

Florida

  • Case Rate per 100,000 = 27,568; grade: D
  • Death Rate per 100,000 = 344; grade: C-
  • Seroprevalence = 58.4%; grade: B-
  • Percent Fully Vaccinated = 66.9%; grade: B-
  • Overall Rank = 35; grade: C-

Georgia

  • Case Rate per 100,000 = 23,689; grade: B
  • Death Rate per 100,000 = 356; grade: D
  • Seroprevalence = 63.8%; grade: D+
  • Percent Fully Vaccinated = 54.7%; grade: D-
  • Overall Rank = 37; grade: D+

Hawaii

  • Case Rate per 100,000 = 17,089; grade: A+
  • Death Rate per 100,000 = 99; grade: A+
  • Seroprevalence = 34.2%; grade: A+
  • Percent Fully Vaccinated = 78.2%; grade: A
  • Overall Rank = 3; grade: A+

Idaho

  • Case Rate per 100,000 = 24,947; grade: C+
  • Death Rate per 100,000 = 275; grade: B
  • Seroprevalence = 67.8%; grade: D-
  • Percent Fully Vaccinated = 54.0%; grade: D-
  • Overall Rank = 31; grade: C

Illinois

  • Case Rate per 100,000 = 24,686; grade: B-
  • Death Rate per 100,000 = 298; grade: B-
  • Seroprevalence = 60.8%; grade: C+
  • Percent Fully Vaccinated = 68.7%; grade: B-
  • Overall Rank = 20; grade: B

Indiana

  • Case Rate per 100,000 = 25,263; grade: C+
  • Death Rate per 100,000 = 350; grade: D+
  • Seroprevalence = 61.2%; grade: C
  • Percent Fully Vaccinated = 54.8%; grade: D
  • Overall Rank = 39; grade: D+

Iowa

  • Case Rate per 100,000 = 24,189; grade: B
  • Death Rate per 100,000 = 302; grade: C+
  • Seroprevalence = 70.7%; grade: F
  • Percent Fully Vaccinated = 61.9%; grade: C+
  • Overall Rank = 32; grade: C

Kansas

  • Case Rate per 100,000 = 26,561; grade: C-
  • Death Rate per 100,000 = 295; grade: B-
  • Seroprevalence = 62.2%; grade: C-
  • Percent Fully Vaccinated = 61.4%; grade: C
  • Overall Rank = 29; grade: C

Kentucky

  • Case Rate per 100,000 = 29706; grade: D-
  • Death Rate per 100,000 = 346; grade: C-
  • Seroprevalence = 56.6%; grade: B-
  • Percent Fully Vaccinated = 57.4%; grade: D+
  • Overall Rank = 42; grade: D

Louisiana

  • Case Rate per 100,000 = 25,226; grade: C+
  • Death Rate per 100,000 = 370; grade: D-
  • Seroprevalence = 68.9%; grade: D-
  • Percent Fully Vaccinated = 53.5%; grade: F
  • Overall Rank = 45; grade: D-

Maine

  • Case Rate per 100,000 = 18,124; grade: A
  • Death Rate per 100,000 = 169; grade: A
  • Seroprevalence = 35.3%; grade: A
  • Percent Fully Vaccinated = 79.5%; grade: A+
  • Overall Rank = 4; grade: A+

Maryland

  • Case Rate per 100,000 = 17,039; grade: A+
  • Death Rate per 100,000 = 239; grade: B
  • Seroprevalence = 49.9%; grade: A-
  • Percent Fully Vaccinated = 75.6%; grade: A-
  • Overall Rank = 9; grade: A-

Massachusetts

  • Case Rate per 100,000 = 25,387; grade: C
  • Death Rate per 100,000 = 293; grade: B
  • Seroprevalence = 52.6%; grade: B+
  • Percent Fully Vaccinated = 78.9%; grade: A
  • Overall Rank = 15; grade: B+

Michigan

  • Case Rate per 100,000 = 24,291; grade: B-
  • Death Rate per 100,000 = 360; grade: D
  • Seroprevalence = 56.9%; grade: B-
  • Percent Fully Vaccinated = 60.1%; grade: C-
  • Overall Rank = 27; grade: C+

Minnesota

  • Case Rate per 100,000 = 25,692; grade: C
  • Death Rate per 100,000 = 226; grade: B+
  • Seroprevalence = 60.8%; grade: C+
  • Percent Fully Vaccinated = 69.1%; grade: B
  • Overall Rank = 18; grade: B

Mississippi

  • Case Rate per 100,000 = 26,788; grade: D+
  • Death Rate per 100,000 = 417; grade: F
  • Seroprevalence = 69.4%; grade: F
  • Percent Fully Vaccinated = 51.8%; grade: F
  • Overall Rank = 51; grade: F

Missouri

  • Case Rate per 100,000 = 23,156; grade: B+
  • Death Rate per 100,000 = 330; grade: C
  • Seroprevalence = 55.7%; grade: B-
  • Percent Fully Vaccinated = 56.0%; grade: D
  • Overall Rank = 17; grade: B

Montana

  • Case Rate per 100,000 = 25,617; grade: C
  • Death Rate per 100,000 = 313; grade: C+
  • Seroprevalence = 47.5%; grade: A-
  • Percent Fully Vaccinated = 56.7%; grade: D+
  • Overall Rank = 19; grade: B

Nebraska

  • Case Rate per 100,000 = 24,798; grade: B-
  • Death Rate per 100,000 = 216; grade: A-
  • Seroprevalence = 65.4%; grade: D
  • Percent Fully Vaccinated = 63.6%; grade: C+
  • Overall Rank = 22; grade: B-

Nevada

  • Case Rate per 100,000 = 23,332; grade: B
  • Death Rate per 100,000 = 349; grade: D+
  • Seroprevalence = 60.1%; grade: C+
  • Percent Fully Vaccinated = 60.8%; grade: C-
  • Overall Rank = 25; grade: C+

New Hampshire

  • Case Rate per 100,000 = 22,740; grade: A-
  • Death Rate per 100,000 = 182; grade: A-
  • Seroprevalence = 33.1%; grade: A+
  • Percent Fully Vaccinated = 70.2%; grade: B+
  • Overall Rank = 6; grade: A

New Jersey

  • Case Rate per 100,000 = 25,355; grade: C+
  • Death Rate per 100,000 = 376; grade: D-
  • Seroprevalence = 60.9%; grade: C+
  • Percent Fully Vaccinated = 75.6%; grade: A-
  • Overall Rank = 33; grade: C-

New Mexico

  • Case Rate per 100,000 = 24,886; grade: B-
  • Death Rate per 100,000 = 356; grade: D
  • Seroprevalence = 49.1%; grade: A-
  • Percent Fully Vaccinated = 71.0%; grade: B+
  • Overall Rank = 21; grade: B-

New York

  • Case Rate per 100,000 = 26,376; grade: C-
  • Death Rate per 100,000 = 347; grade: D+
  • Seroprevalence = 61.5%; grade: C
  • Percent Fully Vaccinated = 76.9%; grade: A
  • Overall Rank = 36; grade: C-

North Carolina

  • Case Rate per 100,000 = 25,355; grade: C
  • Death Rate per 100,000 = 223; grade: B+
  • Seroprevalence = 52.0%; grade: B+
  • Percent Fully Vaccinated = 61.0%; grade: C-
  • Overall Rank = 14; grade: B+

North Dakota

  • Case Rate per 100,000 = 31,620; grade: F
  • Death Rate per 100,000 = 297; grade: B-
  • Seroprevalence data not available
  • Percent Fully Vaccinated = 54.9%; grade: D
  • Overall Rank = 41; grade: D

Ohio

  • Case Rate per 100,000 = 22,999; grade: B+
  • Death Rate per 100,000 = 328; grade: C
  • Seroprevalence = 63.2%; grade: C-
  • Percent Fully Vaccinated = 58.4%; grade: C-
  • Overall Rank = 24; grade: B-

Oklahoma

  • Case Rate per 100,000 = 26,293; grade: C-
  • Death Rate per 100,000 = 360; grade: D
  • Seroprevalence = 69.1%; grade: D-
  • Percent Fully Vaccinated = 57.2%; grade: D+
  • Overall Rank = 47; grade: D-

Oregon

  • Case Rate per 100,000 = 17,038; grade: A+
  • Death Rate per 100,000 = 177; grade: A
  • Seroprevalence = 46.9%; grade: A
  • Percent Fully Vaccinated = 69.9%; grade: B
  • Overall Rank = 5; grade: A

Pennsylvania

  • Case Rate per 100,000 = 21,973; grade: A-
  • Death Rate per 100,000 = 348; grade: D+
  • Seroprevalence = 54.6%; grade: B
  • Percent Fully Vaccinated = 68.4%; grade: B-
  • Overall Rank = 16; grade: B+

Puerto Rico

  • Case Rate per 100,000 = 16,358; grade: A+
  • Death Rate per 100,000 = 131; grade: A+
  • Seroprevalence = 34.3%; grade: A+
  • Percent Fully Vaccinated = 83.0%; grade: A+
  • Overall Rank = 1; grade: A+

Rhode Island

  • Case Rate per 100,000 = 33,226; grade: F
  • Death Rate per 100,000 = 333; grade: C-
  • Seroprevalence = 53.4%; grade: B+
  • Percent Fully Vaccinated = 82.5%; grade: A+
  • Overall Rank = 30; grade: C

South Carolina

  • Case Rate per 100,000 = 28,592; grade: D-
  • Death Rate per 100,000 = 344; grade: C-
  • Seroprevalence = 64.5%; grade: D+
  • Percent Fully Vaccinated = 56.6%; grade: D
  • Overall Rank = 46; grade: D-

South Dakota

  • Case Rate per 100,000 = 26,882; grade: D+
  • Death Rate per 100,000 = 329; grade: C
  • Seroprevalence = 61.3%; grade: C
  • Percent Fully Vaccinated = 61.4%; grade: C
  • Overall Rank = 38; grade: D+

Tennessee

  • Case Rate per 100,000 = 29,715; grade: F
  • Death Rate per 100,000 = 382; grade: F
  • Seroprevalence = 67.4%; grade: D
  • Percent Fully Vaccinated = 54.5%; grade: D-
  • Overall Rank = 52; grade: F

Texas

  • Case Rate per 100,000 = 23,215; grade: B+
  • Death Rate per 100,000 = 298; grade: B-
  • Seroprevalence = 69.7%; grade: F
  • Percent Fully Vaccinated = 61.4%; grade: C
  • Overall Rank = 28; grade: C+

Utah

  • Case Rate per 100,000 = 29,026; grade: D-
  • Death Rate per 100,000 = 147; grade: A+
  • Seroprevalence = 69.2%; grade: D-
  • Percent Fully Vaccinated = 64.3%; grade: C+
  • Overall Rank = 34; grade: C-

Vermont

  • Case Rate per 100,000 = 18,336; grade: A
  • Death Rate per 100,000 = 96; grade: A+
  • Seroprevalence = 28.9%; grade: A+
  • Percent Fully Vaccinated = 81.1%; grade: A+
  • Overall Rank = 2; grade: A+

Virginia

  • Case Rate per 100,000 = 19,912; grade: A
  • Death Rate per 100,000 = 236; grade: B+
  • Seroprevalence = 45.1%; grade: A
  • Percent Fully Vaccinated = 73.1%; grade: A-
  • Overall Rank = 8; grade: A

Washington State

  • Case Rate per 100,000 = 19,609; grade: A
  • Death Rate per 100,000 = 166; grade: A
  • Seroprevalence = 54.3%; grade: B
  • Percent Fully Vaccinated = 72.5%; grade: B+
  • Overall Rank = 7; grade: A

West Virginia

  • Case Rate per 100,000 = 27,938; grade: D-
  • Death Rate per 100,000 = 382; grade: D-
  • Seroprevalence = 54.6%; grade: B
  • Percent Fully Vaccinated = 57.6%; grade: D+
  • Overall Rank = 44; grade: D

Wisconsin

  • Case Rate per 100,000 = 27,604; grade: D
  • Death Rate per 100,000 = 247; grade: B
  • Seroprevalence = 66.7%; grade: D
  • Percent Fully Vaccinated = 65.5%; grade: B-
  • Overall Rank = 40; grade: D+

Wyoming

  • Case Rate per 100,000 = 27,049; grade: D+
  • Death Rate per 100,000 = 313; grade: C
  • Seroprevalence = 62.5%; grade: C-
  • Percent Fully Vaccinated = 51.6%; grade: F
  • Overall Rank = 43; grade: D

The data indicates that during the pandemic, you were best off living on an island (Puerto Rico or Hawaii). If you couldn’t live on an island, then you were best off living in either Vermont or Maine. The states that were the worst to live in during the pandemic were Tennessee, Mississippi, Arkansas, and Alabama.

But the pandemic is not yet over. Today’s epidemiologic data from the CDC shows that we are likely entering a new COVID -19 surge. Since the beginning of the pandemic, we have seen that the percent test positivity starts going up about 2 weeks before the case numbers rise followed a few days later by a rise in hospitalization rates and then about 2 weeks later by a rise in death rates. The graph below shows that the test percent positivity (yellow curve) began to increase on March 19, 2022 and the case numbers then began to increase on April 5, 2022.

The number of COVID-19 hospitalizations (yellow curve in the graph below) then began to rise on April 7, 2022:

The daily death rate began rising on April 27, 2022 (not shown). With a recent societal move toward elimination of masking and social distancing, the number of cases, hospitalizations, and deaths will likely continue to rise in the coming weeks. So, there is still a chance for states to pull up their grades. But given the geographic variation in cultural attitudes toward infection control, I don’t expect this to happen.

April 29, 2022

Categories
Epidemiology

How Do We Overcome Vaccination Hesitancy?

Today, I got my second COVID-19 booster. On December 15, 2020, I was one of the first healthcare workers in the United States to get the newly approved Pfizer vaccine. In the nearly 16 months since then, I’ve had a total of 4 COVID vaccinations, 2 shingles vaccinations, and an influenza vaccination. I’m alive, I’m healthy, and I want to stay that way.

But in my home of Franklin County, Ohio, only 74% of adults are fully vaccinated with the initial doses of COVID vaccines and only 41% of adults are both fully vaccinated and received a booster. Franklin County’s vaccination numbers are only slightly worse than the United States as a whole. We are now approaching 1 million American deaths from COVID-19. More than a third of those have occurred since vaccines were available to all adults making most of these deaths preventable. So, why aren’t Americans getting vaccinated?

Vaccine hesitancy is the intersection of ignorance, cowardice, obstinance, and selfishness. Most people who unvaccinated fall into one or more of these categories. Improving vaccination rates requires different tactics for each of these groups of people.

The four causes of vaccine hesitancy

Ignorance. Ignorance about disease and about vaccines is hard to break. Nevertheless, it is probably the easiest of the four barriers to vaccination to overcome. The ally of ignorance is misinformation. A famous adage (incorrectly attributed to Mark Twain) states: “A lie can travel halfway around the world before the truth is putting on its shoes“. I the era of the internet, cable news, and social media, a better adage is: “A lie can travel around the world ten times before truth gets out of bed in the morning“. A subset of the ignorant is the skeptics who can be educated but will only accept education from members of their own kind. An OSU Buckeye fan will won’t be convinced by a Michigan Wolverine fan but might be convinced by a fellow Buckeye. Science is hard to understand and misinformation is a lot easier to understand. Education about vaccines needs to start in middle school science classes, continue in high school health classes, and continue further in physician offices.

Cowardice. Fear is amplified by ignorance. Like ignorance, misinformation is the ally of fear. Some people fear the metal needle, others fear the stuff that is in the syringe, and others just fear science in general. The great facilitator of fear is gossip. When one person tells another that he got a COVID vaccination and his arm was sore for a day, that story gets told to another person who tells another person, and on and on. By the time the tenth person tells the story, the report is that the vaccination caused the guy so much pain that he passed out, had a heart attack, and became impotent. Although education can help overcome cowardice, reassurance is more powerful, particularly when it comes from people you trust like pastors, sports figures, and movie stars. Once again, tribalism plays a role in reassurance. A Republican who won’t accept any reassurance from a Democrat might listen to a fellow Republican.

Obstinance. Some people are impossibly stubborn and no amount of education or reassurance will change their mind. Obstinance is the realm of the hard-core anti-vaxxers. At one extreme are those people who crave the attention they get by being anti-vaxxers or make money by being anti-vaxxers. This kind of secondary gain is nothing new and was the main motivation of snake oil salesmen, purveyors of patent medicines, and ponzi schemers. Robert F. Kennedy, Jr. and Dr. Sheri Tenpenny are examples of people who make a living by being anti-vaxxers. At the other extreme are those people who just can’t admit that they are wrong about anything and will dig their heels in deeper to try to convince themselves that they were right all along. Some obstinate people look for reasons to justify their decisions. For centuries, obstinate people have used their personal interpretation of 2,000 year old passages from the Torah, the Bible, and the Quran to justify a whole variety of hatreds, unhealthy behaviors, social deviance, and crimes. During the COVID pandemic, obstinate people used similar interpretations to claim religious exemptions from vaccination. Obstinance is hard to overcome and sometimes the only tactic that works is public shame.

Selfishness. People who do not get vaccinated because of selfishness often know that vaccines work. They just figure that if everyone else gets vaccinated then the disease will go away and they won’t need a vaccine. The best friend of selfishness is cowardice and the two often go hand-in-hand. Overcoming selfishness often requires a combination of reassurance and shame. However, unlike obstinance, selfishness can sometimes be overcome by private shame rather than public shame.

How do we fix it?

As healthcare workers, our main tools are education and reassurance. As such, we can have the biggest impact on those who are hesitant to get vaccinated because of ignorance and cowardice. It is tempting to use shame but shame is no more useful in changing ignorance than education is in changing obstinance. The trick is to know one’s audience – we should focus on people who are hesitant to get vaccinated because of ignorance or fear. Wasting time and emotional energy on those whose vaccine hesitancy is motivated by obstinance or selfishness is unproductive, frustrating, and exhausting.

COVID-19 is not the first deadly pandemic that the human race has faced and it certainly will not be the last. But we can learn from our public health failures in vaccination and use that knowledge to lay the foundation for more effective public health measures when the next pandemic comes around. The adults when the next pandemic occurs are the children of today. Our focus needs to be on education and reassurance of our children so that ignorance, cowardice, obstinance, and selfishness does not kill them when they are adults.

This pandemic appears to be waning and there are signs that life may be getting back towards normal. For all of the unvaccinated people who are happy to now be taking off their masks and going to restaurants, you can thank everyone who got a vaccination and made it possible.

…you’re welcome.

April 2, 2022

Categories
Epidemiology

What We Can Learn From The COVID Seroprevalence Study

This week, the latest results of the Nationwide COVID-19 Infection-Induced Antibody Seroprevalence (Commercial laboratories) Study was released. These results estimate the percentage of the population of each state that has been infected with COVID-19 as of the end of December 2022. The results are quite remarkable and indicate that there has been enormous variation in the frequency of the infection among the states and among different age groups.

The commercial laboratories seroprevalence study is done monthly and uses left-over samples of blood drawn by commercial laboratories for routine blood tests. Patients getting tested specifically for COVID-19 are excluded. The antibodies detected in this study are directed against the nucleocapsid antigen and these antibodies are only produced from actual infection by the virus. The COVID vaccines produce antibodies against the spike protein antigens and these are not measured by the tests used in the commercial laboratories seroprevalence study.

Limitations of the seroprevalence study

The methodology of the seroprevalence study was published in the April 2021 edition of JAMA Internal Medicine. Because the samples are anonymous, there are several potential limitations of the study that could affect the prevalence results:

  1. Healthy adults and children are less likely to have routine blood tests. Therefore, people with chronic diseases are more heavily represented in the samples. If patients with chronic diseases are also more likely to get infected with COVID-19, then the results may overestimate the percentage of the population previously infected with COVID.
  2. Because the results depend on blood tests drawn in December 2021 from live patients, those people who died of COVID-19 prior to December 2021 are not included. This results in the study underestimating the percentage of the population infected since the beginning of the pandemic. This limitation can be corrected by adding the number of COVID deaths to the seroprevalence data to get total infection data (see the analysis later in this post).
  3. People who do become infected with COVID-19 frequently have lingering symptoms (“long-haulers”) that could prompt their physicians to order various blood tests and this could result in the the seroprevalence study overestimating the percentage of the population previously infected with COVID.
  4. Because antibody levels decline over time, it is likely that some patients who had COVID-19 infection early in the pandemic no longer have detectable antibodies against the virus. This could result in the study underestimating the percentage of the population infected since the beginning of the pandemic.
  5. People with less access to healthcare due to socio-economic disparities and people who choose to avoid healthcare are less likely to have routine blood tests drawn. These groups include the uninsured, those who choose to not get vaccinated, residents of rural areas, and the poor. These groups are known be at higher risk of becoming infected with COVID-19. This could result in the study underestimating the percentage of the population infected since the beginning of the pandemic.
  6. The number of blood tests from North Dakota, South Dakota, and Wyoming was too low for statistical analysis and so the study does not include seroprevalence rates from these three states.

Despite these limitations, compared to other epidemiology studies, the commercial lab seroprevalence study gives us the most accurate estimate of the percentage of the U.S. population that has had a COVID-19 infection. First, it is likely that the limitations above that result in overestimation are balanced out by those limitations that result in underestimation of the number of infections. Second, it is likely that the above limitations apply more-or-less equally among different states, allowing reasonably accurate comparison of the rates of infected between different states.

Differences between states

The CDC regularly reports on the total number of infections (based on nasopharyngeal PCR or rapid antigen tests) per 100,000 population since the pandemic began. These results indicate a low of 12.2% of the population in Maine to a high of 30.2% of the population in Rhode Island. However, these results depend on COVID test results reported to local health department and underestimates the true number of infections because (1) many infected people are asymptomatic and do not get tested, (2) many infected people use retail COVID tests with results that are not reported to the health department, and (3) many symptomatically infected people choose to not get tested. For these reasons, the seroprevalence studies offer a more accurate measure of the true rates of infection. The commercial lab study indicates enormous variations in the rate of COVID among the states and territories from a low of fewer than 1 out of every 10 people to a high of nearly 1 out of every 2 people

States with the lowest rates of infection. 15 states and territories had antibody prevalence rates of less than 30% of their population. The lowest rates were in Puerto Rico (9.7% of the population previously infected) and Hawaii (11.1% of the population previously infected. Living on an island was protective against becoming infected. Rhode Island (which is not really an island) is notable because by nasopharyngeal testing, it has had the highest rate of infection in the U.S. but by seroprevalence testing, it has had one of the lowest rates of infection. Rhode Island has the third highest vaccination rate (78.1% of its population) in the country. It is likely that for Rhode Island, the seroprevalence data is more accurate than the case rates determined by nasopharyngeal testing. The common feature of these 15 states & territories is that they all have high COVID vaccination rates with greater than 65% of their population fully vaccinated. We’ll give these states a grade of “A” for controlling the pandemic.

States with intermediate rates of infection. 19 states had rates of infection between 30-40% of their populations. We’ll give these states a grade of “C” for controlling COVID-19. With a United States overall average of 33.5% of the population previously infected, these states performed about average overall.

States with high rates of infection. 15 states had antibody prevalence rates above 40%. Iowa and Montana tied for the highest rate of infection with 47.7% of their population having been infected during the pandemic. These states also have low COVID vaccination rates with all of these states having fewer than 65% of their population fully vaccinated. This provides additional evidence that vaccination prevents infection. We’ll give these states a grade of “F” for controlling the pandemic. Lamentably, my own state of Ohio is the 4th worst in the country for antibody prevalence. The tone for Ohio’s response to COVID-19 was set early in the pandemic when AR-15 wielding anti-maskers protested in the front yard of our state’s Director of Public Health when she was trying to get her children off to school… she resigned, leaving Ohio with no health department director for months.

Differences between genders

Overall, there was no difference in the antibody prevalence among men (33.2%) and women (33.8%). In most states, the difference in rate of infection between men and women was less than 5 percentage points. However, three states had gender differences of more than 6 percentage points:

  • Pennsylvania: 30.3% of men and 39.6% of women
  • Indiana: 37.4% of men and 45.0% of women
  • Montana: 51.4% of men and 43.9% of women

Differences by age

There was a striking relationship between age and seroprevalence of COVID-19 antibodies with the study indicating that far more younger Americans have been infected than older Americans:

In this table, the second column from the left is the seroprevalence of COVID-19 antibodies indicating past infection for each age group. The third column is the percentage of the population in each age group that has died of COVID since the pandemic began. The fourth column is the sum of the seroprevalence plus the percentage of each age population that died of COVID; this column gives a more accurate number of the total percentages of Americans in each age group that became infected with COVID and then either lived (seropositive group) or died of COVID (% died group). Even correcting for the fact that most of the deaths from COVID occurred in people over age 65, it is still clear that younger Americans were more likely to become infected than older Americans.

The causes for the age differences in infection rates is likely multifactorial. Younger people were more likely to have employment or school exposures whereas retired older people were more likely to be able to isolate at home during the pandemic. Younger people tend to live in larger households with children and adults together whereas older people are more likely to live with only their spouse or to live alone. Older Americans are more likely to be vaccinated than younger Americans. Older people are also more risk-adverse than younger people when it comes to masking and social distancing in public areas.

So what does all of this mean?

There are two ways to get immunity to COVID-19: (1) get vaccinated or (2) get infected. Immunity causes a reduction in the chance of subsequent infection (or re-infection). Immunity causes a greater reduction in the chance of hospitalization from infection (or re-infection). And immunity causes an even greater reduction in the chance of dying from infection (or re-infection).Which type of immunity is better? It appears that vaccination gives better immunity than past infection. But even if the two give equivalent immunity, the risk of dying from a COVID vaccine is negligible whereas the risk of dying from a COVID infection is 1 out of 85 – getting immunity from vaccination is far safer than getting immunity from infection.

Epidemiologists talk of “herd immunity” when enough of the population has immunity from either vaccination or past infection. Most epidemiologists now believe that between 75% and 90% of the population must have immunity in order to bring an end to the pandemic by herd immunity. Because people can get re-infected with COVID, the coronavirus will probably never go away but if we achieve herd immunity, we should be able to keep the number of new infections relatively low. More importantly, herd immunity should keep the number of hospitalizations and deaths extremely low. In other words, the goal of herd immunity is not to prevent all COVID infections but instead to prevent COVID hospitalizations and COVID deaths. Indeed, the current data indicates that most of the people who are hospitalized with COVID are unvaccinated and almost all of the people who are die of COVID are unvaccinated.

Currently, we know that 64% of the U.S. population has immunity by being fully vaccinated. We know that 33.5% of the U.S. population has immunity by having had a past COVID infection. What we do not know is to what extent these two populations overlap; that is, how many people who have had a COVID vaccination also had a COVID infection (either before or after they got their vaccination). Another way of looking at this is that we do not know how many people have immunity from either vaccination or past infection. Certainly more than 64% of the U.S. population has immunity but probably less than 90% has immunity.

To forecast what COVID may look like in future years, consider rhinoviruses. They cause 1/3 to 1/2 of all common colds. Given that the average person gets 2-3 colds per year, most people become infected with a rhinovirus every year and nearly everyone has been infected at least once by adulthood. Because re-infection with COVID can occur, it is likely that COVID will continue to circulate in the community for the indefinite future. Eventually, nearly everyone will have either been infected or been vaccinated. At that point, hospitalization or death from COVID should become uncommon. In other words, COVID won’t go away but it won’t kill you in the future.

The primary goal of medicine is to prevent people from becoming severely ill or dying from infections. A more aspirational (but usually unobtainable) goal is to prevent all infections, even mild ones. As long as there are people with weak immunity against COVID (either because they are not vaccinated or they have not yet been infected), then COVID will continue to cause hospitalization and death.

Therefore, our realistically obtainable goal in public should be to prevent severe COVID infection and prevent death from COVID. In that sense, we are reaching a point where we should not be looking at vaccine mandates but instead be looking at immunity mandates. In other words, instead of requiring all of a business’s employees to be vaccinated, we should be requiring all employees to either be vaccinated or have antibodies indicating past infection.

Immunity mandates should become our new public health doctrines – for our workplaces, our schools, and our military. For me personally, sign me up for a second booster when they become available… but I’ll pass on getting a COVID-19 infection to keep my immunity up.

February 5, 2022